HSM

HISTAMINE

Created:	1999-07-08
Last modified:	2011-06-04

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58 entries where HSM is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	17
Chiral Atom Count	0
Bond Count	17
Aromatic Bond Count	5

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Chemical Component Summary
Name	HISTAMINE
Systematic Name (OpenEye OEToolkits)	2-(1H-imidazol-4-yl)ethanamine
Formula	C₅ H₉ N₃
Molecular Weight	111.145
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	n1c(cnc1)CCN
SMILES	CACTVS	3.341	NCCc1c[nH]cn1
SMILES	OpenEye OEToolkits	1.5.0	c1c(nc[nH]1)CCN
Canonical SMILES	CACTVS	3.341	NCCc1c[nH]cn1
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1c(nc[nH]1)CCN
InChI	InChI	1.03	InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChIKey	InChI	1.03	NTYJJOPFIAHURM-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB05381
Name	Histamine
Groups	approved investigational
Description	A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Synonyms	Histamine phosphate Histamine beta-aminoethylglyoxaline 5-imidazoleethylamine 4-imidazoleethylamine beta-aminoethylimidazole Histamine dihydrochloride 2-(4-imidazolyl)ethylamine 1H-Imidazole-4-ethanamine
Brand Names	Mancore Muscle Mend Roll-ON Pain Reliever Abee Med Camphomex Midalgan Hand and Wrist Pain Cream BAKERS BEST Arthritis Pain Relief Cream with Hemp and Lavender Glucosamine Cream EXTRA STRENGTH AMINO ACTIVE Topical Analgesic Cream Histamine Phosphate Injection USP Liq Sc Australian Dream Hand and Wrist Pain Positive Skin Test Control - Histamine Arthritis Relief Arthrocare Lotion Bakers Best Arthritis Pain Relief with Hemp Seed Histamine Positive Skin Test Control Alo Therapeutic Massage Pain Relieving MINTED LEAF Odorless Histamine DHCl Pain Relief and Hemp Extract Rematex REVIVE SCIENCE Natural Hemp Pain Relief Rub DR. MIKES Ponos Pain Relief Cream Roll-On ROPANA Pain Relief Cream Md Science Cannabidiol Australian Dream Carpal Tunnel Pain Bakers Best Arthritis Pain Relief Ceplene TerraFreeze Pain Relief Histatrol Australian Dream Back Pain Simanix CVS Arthritis Pain Relief Dr. Freds MIRACLE RUB Ponos Natural Pain Relief MUSCLESHOK Sport Raging Kakapo Pain Relieve Positive Skin Test Control-histamine Histamine Phosphate Injection USP, 1mg/ml Pain Relieving Arthritis Minted Leaf Odorless Pain Relief Walgreens Arthritis Pain Relief Cream HAVASU HEMP Soothing Pain Relief Rub Alo Therapeutic Massage Arthritis Pain Relief MUSCLESHOK Back Pain PainMD Max Histamine DHCl 0.10 Percent ActivOn Ultra Strength Arthritis Histamine DHCl 0.10 Percent and Menthol 2 Percent Md Science Cannabigerol Arthritis Pain Relief Cream Royal Labs Hemp Recover Australian Dream Pain Relieving Arthritis
Indication	Histamine phosphate is indicated as a diagnostic aid for the evaluation of gastric acid secretory function.
Categories	Adjuvants, Immunologic Amines Antineoplastic and Immunomodulating Agents Autacoids Biogenic Amines Biogenic Monoamines Biological Factors Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 Enzyme Inhibitors Diagnostic Agents Ethylamines Gastric Function Histamine Agents Histamine Agonists Imidazoles Inflammation Mediators Neurotransmitter Agents OCT1 substrates OCT2 Inhibitors OCT2 Substrates Other Diagnostics Tests for Gastric Secretion
ATC-Code	L03AX14 V04CG03
CAS number	51-45-6

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Histamine H1 receptor	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLY...	unknown	agonist
Histamine H2 receptor	MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLR...	unknown	agonist
Histamine H3 receptor	MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVL...	unknown	agonist
Histamine H4 receptor	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRS...	unknown	agonist
Synaptic vesicular amine transporter	MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYS...	unknown
Histamine N-methyltransferase	MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDT...	unknown	substrate
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	substrate,inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown
Solute carrier family 22 member 3	MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYW...	unknown	inhibitor
Organic cation/carnitine transporter 2	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682