HSM

HISTAMINE

Created:	1999-07-08
Last modified:	2011-06-04

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42 entries where HSM is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	17
Chiral Atom Count	0
Bond Count	17
Aromatic Bond Count	5

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Chemical Component Summary
Name	HISTAMINE
Systematic Name (OpenEye OEToolkits)	2-(1H-imidazol-4-yl)ethanamine
Formula	C₅ H₉ N₃
Molecular Weight	111.145
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	n1c(cnc1)CCN
SMILES	CACTVS	3.341	NCCc1c[nH]cn1
SMILES	OpenEye OEToolkits	1.5.0	c1c(nc[nH]1)CCN
Canonical SMILES	CACTVS	3.341	NCCc1c[nH]cn1
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1c(nc[nH]1)CCN
InChI	InChI	1.03	InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChIKey	InChI	1.03	NTYJJOPFIAHURM-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB05381
Name	Histamine
Groups	investigational approved
Description	A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Synonyms	Histamine phosphate 2-(4-imidazolyl)ethylamine 5-imidazoleethylamine beta-aminoethylglyoxaline beta-aminoethylimidazole 1H-Imidazole-4-ethanamine Histamine dihydrochloride 4-imidazoleethylamine Histamine
Brand Names	Dr. Freds MIRACLE RUB Royal Labs Hemp Recover Alo Therapeutic Massage MUSCLESHOK Sport HAVASU HEMP Soothing Pain Relief Rub Md Science Cannabigerol Bakers Best Arthritis Pain Relief Ponos Natural Pain Relief Mancore Muscle Mend Roll-ON Pain Reliever AMINO ACTIVE Topical Analgesic Cream Histamine DHCl 0.10 Percent Positive Skin Test Control-histamine Simanix Australian Dream Hand and Wrist Pain ActivOn Ultra Strength Arthritis Raging Kakapo Pain Relieve BAKERS BEST Arthritis Pain Relief Cream with Hemp and Lavender Histamine Positive Skin Test Control TerraFreeze Pain Relief Australian Dream Carpal Tunnel Pain Arthritis Relief Histamine DHCl 0.10 Percent and Menthol 2 Percent ROPANA Pain Relief Cream Ceplene DR. MIKES Ponos Pain Relief Cream Roll-On Histamine Phosphate Injection USP, 1mg/ml Positive Skin Test Control - Histamine Walgreens Arthritis Pain Relief Cream Alo Therapeutic Massage Pain Relieving MINTED LEAF Odorless Histamine DHCl Pain Relief and Hemp Extract Arthritis Pain Relief Cream Minted Leaf Odorless Pain Relief Glucosamine Cream EXTRA STRENGTH Histamine Phosphate Injection USP Liq Sc REVIVE SCIENCE Natural Hemp Pain Relief Rub CVS Arthritis Pain Relief Midalgan MUSCLESHOK Back Pain Australian Dream Back Pain Histatrol Abee Med Rematex PainMD Max Pain Relieving Arthritis Australian Dream Pain Relieving Arthritis Hand and Wrist Pain Cream Arthritis Pain Relief Bakers Best Arthritis Pain Relief with Hemp Seed Md Science Cannabidiol Arthrocare Lotion Camphomex
Indication	Histamine phosphate is indicated as a diagnostic aid for the evaluation of gastric acid secretory function.
Categories	Adjuvants, Immunologic Amines Antineoplastic and Immunomodulating Agents Autacoids Biogenic Amines Biogenic Monoamines Biological Factors Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 Enzyme Inhibitors Diagnostic Agents Ethylamines Gastric Function Histamine Agents Histamine Agonists Imidazoles Inflammation Mediators Neurotransmitter Agents OCT1 substrates OCT2 Inhibitors OCT2 Substrates Other Diagnostics Tests for Gastric Secretion
ATC-Code	L03AX14 V04CG03
CAS number	51-45-6

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Histamine H1 receptor	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLY...	unknown	agonist
Histamine H2 receptor	MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLR...	unknown	agonist
Histamine H3 receptor	MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVL...	unknown	agonist
Histamine H4 receptor	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRS...	unknown	agonist
Synaptic vesicular amine transporter	MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYS...	unknown
Histamine N-methyltransferase	MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDT...	unknown	substrate
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	substrate,inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown
Solute carrier family 22 member 3	MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYW...	unknown	inhibitor
Organic cation/carnitine transporter 2	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682