HYP

4-HYDROXYPROLINE

Created:	1999-07-08
Last modified:	2024-09-27

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10 entries where HYP is found as a standalone ligand380 entries where HYP is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	18
Chiral Atom Count	2
Bond Count	18
Aromatic Bond Count	0

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Chemical Component Summary
Name	4-HYDROXYPROLINE
Synonyms	HYDROXYPROLINE
Systematic Name (OpenEye OEToolkits)	(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid
Formula	C₅ H₉ N O₃
Molecular Weight	131.13
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C1NCC(O)C1
SMILES	CACTVS	3.341	O[CH]1CN[CH](C1)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C1C(CNC1C(=O)O)O
Canonical SMILES	CACTVS	3.341	O[C@H]1CN[C@@H](C1)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C1[C@H](CN[C@@H]1C(=O)O)O
InChI	InChI	1.03	InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChIKey	InChI	1.03	PMMYEEVYMWASQN-DMTCNVIQSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB08847
Name	Hydroxyproline
Groups	experimental
Description	Hydroxyproline is a neutral heterocyclic protein amino acid. It is found in collagen and as such it is common in many gelatin products. Hydroxyproline is mostly used as a diagnostic marker of bone turnover and liver fibrosis. Therapeutically, hydroxyproline is being studied as an an experimental medicine but is approved in France as a combination topical gel product called Cicactive for small, superficial wounds.
Synonyms	Hydroxyproline trans-4-Hydroxy-L-proline trans-L-Hydroxyproline
Brand Names	Isa Knox Wrinkle Decline Double Effect Rf3 Wrinkle Eye Filler O Hui Wrinkle Science Deep Wrinkle Treatment Gongjinhyang Mi Luxury Base Cathycat Chewy CREAM FOUNDATION SPF23 PA WHITENING ANTI WRINKLE 23 Ohui Skin Science Age Recovery Cell Lab The History of Whoo Bichup Ja Saeng Essence Ohui Skin Science Age Recovery Cell Lab Pramin Isa Knox Ageless Serum Makeup Base 10 Ohui Skin Science Age Recovery Cell-lab Essential Ohui The First Cell Revolution Age Control Sun Block Ouhi Cell Power No 1 Essence Sooryehan Onbit Essence Foundation 23 Sooryehan Onbit Lifting Base Isaknox Ageless Serum Moist Pearl Base Ohui Skin Science Age Recovery Cell Lab Essence Soo Rye Han Dabityoon Jiyoon Foundation 23 Isaknox Timeless Essence Makeup Base 70 Cathycat Chewy CREAM FOUNDATION SPF23 PA WHITENING ANTI WRINKLE 21 The History Of Whoo Gongjinhyang Mi Pact 2 Gongjinhyang Mi Luxury Foundation 1 Sooryehan Onbit Essence Foundation 25 Isaknox Timeless Essence Foundation 21 Isa Knox Wrinkle Decline Double Effect Rf3 Wrinkle Isaknox Timeless Essence Foundation 23 Ouhi Cell Power No 1 Eye The History Of Whoo Gongjinhyang Mi Pact 1 Ohui Skin Science Age Recovery Cell Lab Eye Ageless Foundation 23 Gongjinhyang Mi Luxury Foundation 2 Isa Knox Tervina Repair Foundation Bb Soo Rye Han Dabityun Jiyun Foundation 21 Isa Knox Smart Bb Sun OHUI Wrinkle Science wrinkle repair eye O Hui Wrinkle Science Wrinkle Repair
Indication	Used in France as a combination product for the treatment of small, superficial wounds.
Categories	Amino Acids Amino Acids, Cyclic Amino Acids, Peptides, and Proteins Imino Acids
CAS number	51-35-4

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Proton-coupled amino acid transporter 1	MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWF...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682