Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the urine of patients with neuroblastoma and pheochromocytoma.
Synonyms
Pyroguaiac acid
Guaiacol carbonate
o-guaiacol
o-hydroxyanisole
2-methoxyphenol
Guaiacol hydrochloride
1-hydroxy-2-methoxybenzene
o-Methoxyphenol
2-methoxyl-4-vinylphenol
Guaiacol
Pyrocatechol monomethyl ether
Brand Names
Valda Pastilles
Gouttes Dentaires
Analgesic Balm
Demo-cineol Adultes/adults
Creo-rectal Adultes/adults
Jamp-cough Suppositories Adult
Valda Pastilles Lemon Flavoured
Creo-rectal Enfants/children
Dry Socket
Demo Cineol Inj
Dentalgar Liq
Jamp-suppositories Children
Pastilles Valda
Demo-cineol Enfants/children
Creo-rectal Nourrisson
Indication
It is used medicinally as an expectorant, antiseptic, and local anesthetic. Guaiacol is used in traditional dental pulp sedation, and has the property of inducing cell proliferation; guaiacol is a potent scavenger of reactive oxygen radicals and its radical scavenging activity may be associated with its effect on cell proliferation.
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
