DrugBank ID DB00281 Name Lidocaine Groups Description Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication [T583]. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures [F4349, L5930, L5948]. It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations [F4349, L5930, L5948]. In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others [F4349, L5930, L5948]. As a result, lidocaine is also considered a class Ib anti-arrhythmic agent [L5930, L5948, F4468]. Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation [A177625]. Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines [L6055]. Synonyms α-diethylamino-2,6-dimethylacetanilide Lidocaine Lignocaine 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide 2-(Diethylamino)-2',6'-acetoxylidide
Lidocaine hydrochloride Lidocaina alpha-diethylamino-2,6-dimethylacetanilide Lidocaína Lidocainum Lidocaine hydrochloride anhydrous more Brand Names ManaMed Lidocaine 4% Pain Relieving Gel Patch Walgreens Burn relief P-Care D80MX LidoReal-30 4% Topical Patch ECOLAB Burn
Burn relief aloe Daylogic Fonow Base Numb Topical Anorectal miaderm-L radiation relief FIRST BXN Mouthwash First Aid Only Burn BLUE ACME SLEEVE FIRST AID Contains 1000 PIECES CVS Health Antiseptic Wound Wash LiProZonePak 4088 First Aid Kit XYLOCAINE- MPF (LIDOCAINE HCl ) 4198 First Aid Kit Disposable Convenience Kit (Single Shot Epidural) Standard ANSI First Aid LIDOCAINE HCl and EPINEPHRINE Lidocaine HCl Jelly 2% Premium HEMP Pain Relief Polysporin for Kids Glydo Lidocaine HCl Topical Solution Healthy Wise Pain Relief Lidocaine Patch GFA First Aid 4353 First Aid Kit Harmony Neur Pain Relief Lidocaine 15% / Phenylephrine HCl 0.25% / Prilocaine 5% Prilo Patch Dyural L Kit Pain free IV CVS Health Cold and Hot Roll-On Antibacterial Lidocaine Wound Gel DAYMARK FAK-35 First Aid Lidodose Sheffield Lidocaine THERA CARE 24hrs Lidocaine Patch Walg Aftrsn Burn Relief 4128 First Aid Kit Oraqix 4273 First Aid Kit Curist Hemorrhoid Relief Welmate Lidocaine Pain Relieving Patch P-Care K40MX Salonpas LIDOCAINE Pain Relieving Burn N Bite Lido-Sorb External MAXOCAINE Topical Anesthetic Anorectal Provenza Velma Pain Relief Patch Extra Strength Liquid Hemorrhoid Relief Gel Coralite Odor Free Pain Relief Maximum Strength Hemorrhoidal Relief Bactine Pain Relieving Lignospan Forte 4172 First Aid Kit CLM Patch Large ANSI First Aid Kit Physician Force Maximum Strength Pain Relief TLC Plus Anesthetic G Aspercreme with Lidocaine Dry Freds Antiseptic Wash Hawaiian Tropic After Sun Après Soleil Sunburn Relief Soulagement Des Coups De Soleil CANNA NUMB Pain Relief Pantin DermacinRx Lidotral Jampocaine 2% Viscous Solution 4267 First Aid Kit Burn Jel Cannabicool Pain Relieving Lidocaine Roll-On First Aid Burn Triple Antibiotic CVS Health Maximum Strength Lidocaine Pain Relief Cream Plus Menthol Elite 4149 First Aid Kit ReadySharp-P40 Dexlido-M Kit Adellina TATTOO NUMBING Lido Rx Icy Hot with Lidocaine No-Mess Livixil Pak Leader Lidocaine Premjact KDS Lab Liquid Styptic CVS Health Lidocaine Pain Relief Plus Menthol 4156 First Aid Kit Naturally HL Extra Strength Hand Care Dollar General Pain Relieving Patch with Lidocaine Burn with Lidocaine Electrum Numb Anesthetic Acme Home/Office/Auto Kit DermacinRx Prikaan 4311 First Aid Kit INTIMALE Maximum Strength Delay Lidocan VI Xylocaine 1.5% W Epinephrine 1:200000 Test Dose CVS Health Lidocaine Pain Relief Cicloferon Instant Burn Relief Aloe Extra CVS Good Sense endure Glycerin, Lidocaine, Petrolatum, and Phenylephrine Hydrochloride 4265 First Aid Kit Point Of Care L5 OKeeffes Healthy Feet Pain Relief Cream Lipocaine 5 Lido-K Diclona Patch Lidosite Aubio Life Sciences Lip Inkeeze Original B Numb Unburn-gel 2.5% Planticin Advanced Topical Pain Relief Medi-derm / L With Lidocaine Rx DG health POWERECT Max Power Male Delay Pain and Itch Relief 4% Lidocaine K-Mart SmartSense First Aid Contains 101 Pieces RITE AID Maximum strength pain relieving Bene Patch Burn Ease 4220 First Aid Kit Md Science Cannabigerol 4322 First Aid Kit 4306 First Aid Kit Desert Harvest RELEVEUM Lidocaine Hydrochloride Lipritin II Restore Lidocaine Pain Relief Cream 4300 First Aid Kit Anesthetic Antibiotic Free Wound Gel and Pain Relief K40-lido Lorenza Pain Relief Patch Comfortox Lidocaine Pro-C-Dure 2 Kit Senstend Octocaine 100 4087 First Aid Kit DyNAmic Plus Pak Kit 4291 First Aid Kit Lidocaine plus Menthol Satohap Lidocaine 4% Menthol 1% Pain Relieving Cream 4278 First Aid Kit Lidocaine HCl 4% Venipuncture CPI LidoVir BZ Step Pain Relief Cream Laryng O Jet Kit Burn Relief Professional Bio-Kool Terrasil Rash and Pain Relief XeroBurn Burn Gel Lidocan IV Fruit of the Earth Sun Town City 4247 First Aid Kit Paracentesis Tray W Boasberg Catheter Set Odynia-UUltra Patch Ultra Patch LidoStat Ez Pain Relieving Lido Pain Relief Steady Freddy biochemistry PAIN RELIEF FOOT ACTIVE AsperFlex MAX Tiger delayspray Doctor Butlers Numb It All Cream 4086 First Aid Kit 4336 First Aid Kit Walgreens Cooling AfterBurn Roll-On Pain Doctor Butlers Hemorrhoid and Fissure External Pain Formula Pentican ReadySharp Anesthetics plus MethylPrednisolone 80 Xylocaine 1.5% Wound Debridement Kit Lidocaine Hydrochloride and Hydrocortisone Acetate Laryng-O-Jet Prikaan Lite K-Mart SmartSense First Aid Contains 303 Pieces EPIC Burn Cream Medi-First Plus Burn Cream NeuroMed AR Sera Relief Ultimate Rapid Soothing Creme Will Relieve Dyural 80-LM Zylotrol Maximum Pain 4362 First Aid Kit Easy Care First Aid AfterBurn 4224 First Aid Kit Swift River Pain Relief Curacaine Leader 4329 First Aid Kit Ritual Tattoo Reveal Foam Permavan External Patch 4373 First Aid Kit Gen7T Hot and Cold Cream with Lidocaine Pain Relieving Relador Pak with Occlusive Dressing 4258 First Aid Kit First Aid Kit 64058024 Analgesic SCLERA CARE Topical Anesthetic Gel MLK F1 Kit DOCTORS TOUCH Erase The Pain Lidocaine Genuine First Aid First Aid Antiseptic Pain Relieving Cream Priloxx LP External Kit Absorbine jr. 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with Aloe Dermatool Hemorrhoidal 4299 First Aid Kit Kroger Pain Relief Lidocaine Patch Lidothol Gel Zensa Lidocaine HCl and Hydrocortisone Acetate Pain Itch Relief Stag 9000 DelaySpray for men Lidotral 3.88% Roll on Lidocaine Pain Relief with Lavender Yowch for minor burns by Pain Balm 4313 First Aid Kit Extra Strength Sunburn Relief Arrow Multi-lumen Central Venous Catheter Kit Duloxicaine Simply Numb Endure Toplast Pain Relief Lidocaine 4percent plus Menthol 1percent HemAway RECOVERY Numbing Mcl SECONDARY NUMB Lidocaine Phenylephrine Gel Kroger Aloe Vera Pain Relieving Solarcaine Medicated First Aid Lotion Coachs First Aid Contains 102 Pieces Pain Relief Roll-on 4286 First Aid Kit Lidocaine MaL Top Safety First Aid Burn Cream Synvexia Epidural Anesthesia Tray CVS Antiseptic Wash Lidopro Harmony NeuroComfort 4% Lidocaine Pain Relief Cream-Gel 1000mg Zcaine Dyural 80 LM-C Lidocaine Hydrochloride Injection USP Lidovex HemRid Anorectal Cream H-Releve Hemorrhoidal Lipovite LIDOCAINE PAIN RELIEF Gel-Patch Solmate Burn Relief Gel Lidotral Five Percent Stud 100 ARC FIRST AID Contains 404 PIECES Lidocaine 2% and Epinephrine 1:100,000 Lmx5 Lidocaine Anesthetic Cream Trifena Alocane Severe Sunburn TopCare Pain Relief Patch Lidocan VII Lidocaine 0.2% In 5% Dextrose Inj 1st Medxpatch With Lidocaine 4%-rx MAKESENSE First Aid 4134 First Aid Kit FIRST AID Contains 202 PIECES First Aid GNP Zeyocaine SIMPLY VITAL HEMORRHOID and ANORECTAL RELIEF Lidocaine Hydrochloride Topical Solution USP Lidocaine Anorectal Temporary Pain Relief Spray Fossaoprin SPG2 Sting Master Ocean Breeze Pain Relief Pain Relief Patch Lidocaine 30% Numstick Ear Pain MD (E007) Hot and Cold Cream with Lidocaine- RA Pain Relieving Numb Skin curacaine Transdermal Corporation Bed Bug Instant Bite Relief 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection USP Amniocentesis Tray 1% 4370 First Aid Kit LifeStyles EPIC Male Genital Desensitizer Walgreens Hemorrhoidal Pain Relief 4022 First Aid Kit First Aid Antiseptic Pain Relieving Cream Bio-Scriptives Lidum Topical Analgesic Lidocaine 2% and Epinephrine 1:50,000 Procicept L Lidocaine 4% Alocane On The Go Meijer Lidocaine Pain Relief Patch Assortment Medium Hemorrhoidal Reciphexamine Medi-sulting Topical Pain Relief Super-Stop BloodClotter 4402 First Aid Kit First Aid Only First Aid/ Burn Numbing Cream Harmony Hemp NeuroComfort Pain Relief Lotion500 4197 First Aid Kit Lidocaine Hydrochloride Injection USP 2% Xylocaine Dental Lidocaine HCl 2% and Epinephrine 1:100,000 Aramark Burn Walgreens Nerve Pain Relieving Topical Analgesic Rite aid Pain Relief Cream Lidocaine 4% DG Health Pain Relieving Maxilene 4 Aloe Vera Gel Pain Relieving Cleansing Pain Relieving 4 Lidocaine Topical Anesthetic 4074 First Aid Kit Loxyine Gabapal 4260 First Aid Kit After Sun Burn Relief Lidocaine Continuous Spray Lidocaine 4 Percent and Menthol 1 Percent Roll-On Bio-Scriptives Lidum Hemorroidal (Anorectal) Aramark Blood Clotting Lido GB-300 Genetic Amniocentesis Tray Kit NULIDO Lidocaine Patch Plus Menthol Pharmacist Choice Pain Relief Patch Lidoderm Tylenol Precise Cooling Pain Relieving Electrum Numb Foam PainPatrol CBD Pain Relief with Lidocaine Just Cbd Relief Soothing Numb Squeeze Xylocaine Ointment 5% Ketorocaine L Kit 4289 First Aid Kit Lidothal Relief Panama Jack Burn Relief Gel with Lidocaine BurnZone CANNA NUMB Roll On DermacinRx Lexifen Hempvana Ultra Strength Pain Relief Cream - Night Swabplus Piercing Care Swabs Ultimate Lidocaine Pain Relief Patch Lidocaine Hydrochloride Injection USP 0.5% 4043 First Aid Kit 4138 First Aid Kit 4375 First Aid Kit ARC FIRST AID Contains 303 PIECES HARDCASE LidoRxKit 4099 First Aid Kit CBD Pain Patches CVS Pain Relieving First Aid Antiseptic Burn Relief Kol-Down Mlp A-1 Renovo Lido5 Walgreens First Aid Antiseptic CVS Health All Purpose Kit 4085 First Aid Kit 4013 First Aid Kit Burn ReliefPreferred Plus Ph Preferred Plus Pharmacy Easy Care First Aid Kit - Comprehensive Aspercreme Lidocaine with Eucalyptus Essential Oil DCH Nerve Pain Relief Roll-On Professional Medicated DNA Collection GPL Pak 4017 First Aid Kit Xylocaine 1% Xylocaine Dental Lidocaine Hydrochloride 2% and Epinephrine 1:50,000 Med Numb Dr Sabharwals Fast Freeze Lidocaine Roll-On 4090 First Aid Kit Green Guard Derma-Caine Burn Toplast Pain Relief Lidocaine 4percent HUMCO Mercuroclear Foster and Thrive Neurozyl Xyralid Leader PAIN RELIEF PATCHES Pleura-seal Thoracentesis Kit LidoCream 5 Burn Mist 4131 First Aid Kit Lidotral 3.88 Percent Plus Hydrocortisone 1 Percent Cacitrix First Aid Research Bacitraycin Plus Maximum Vertical Scar Zone Burn Topical Analgesic and Antiseptic Cutiecaine Md Science Cannabidiol Target Up and Up After Sun Cooling Veltrix Topicaine Cold Sore TREATMENT Lidosolve Pain Relief Doloracin/l Rx With Lidocaine more Indication Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks [F4349, L5930]. Categories Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Agents that reduce seizure threshold Amides Amines Analgesics and Anesthetics
Anesthetics Anesthetics for Topical Use Anesthetics, Local Anilides Aniline Compounds Antiarrhythmic agents Antiarrhythmics, Class I Antiarrhythmics, Class Ib Antipruritics and Local Anesthetics Antipruritics, Incl. Antihistamines, Anesthetics, Etc. Cardiac Therapy Cardiovascular Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (moderate) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2A6 Substrates Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C18 Substrates Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Local Anesthesia Local Anesthetics (Amide) Membrane Transport Modulators Methemoglobinemia Associated Agents Nervous System Neuraxial Anesthetics Ophthalmologicals Otologicals P-glycoprotein inhibitors Peripheral Nervous System Agents Sensory System Agents Sodium Channel Blockers Throat Preparations Vasoprotectives Voltage-Gated Sodium Channel Blockers more ATC-Code S01HA07 D04AB01 R02AD02 C01BB01 S02DA01
N01BB52 C05AD01 N01BB02 more CAS number 137-58-6 
