MZR

5-hydroxy-1-(beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide

Created:	2011-07-12
Last modified:	2020-06-05

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1 entries where MZR is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	31
Chiral Atom Count	4
Bond Count	32
Aromatic Bond Count	5

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Chemical Component Summary
Name	5-hydroxy-1-(beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide
Synonyms	Mizoribine
Systematic Name (OpenEye OEToolkits)	1-[(2R,3R,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-5-oxidanyl-imidazole-4-carboxamide
Formula	C₉ H₁₃ N₃ O₆
Molecular Weight	259.216
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	O=C(c1ncn(c1O)C2OC(C(O)C2O)CO)N
SMILES	CACTVS	3.370	NC(=O)c1ncn([CH]2O[CH](CO)[CH](O)[CH]2O)c1O
SMILES	OpenEye OEToolkits	1.7.2	c1nc(c(n1C2C(C(C(O2)CO)O)O)O)C(=O)N
Canonical SMILES	CACTVS	3.370	NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1O
Canonical SMILES	OpenEye OEToolkits	1.7.2	c1nc(c(n1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)O)C(=O)N
InChI	InChI	1.03	InChI=1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1
InChIKey	InChI	1.03	HZQDCMWJEBCWBR-UUOKFMHZSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB12617
Name	Mizoribine
Groups	investigational
Description	Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.
Synonyms	BREDININ Mizoribine
Categories	Analgesics Analgesics, Non-Narcotic Anti-Infective Agents Anti-Inflammatory Agents Antibiotics, Antineoplastic Antimalarials Antineoplastic Agents Antiparasitic Agents Antiprotozoals Antirheumatic Agents Enzyme Inhibitors Immunologic Factors Immunosuppressive Agents IMP Dehydrogenase, antagonists & inhibitors Nucleic Acids, Nucleotides, and Nucleosides Nucleosides Peripheral Nervous System Agents Sensory System Agents
CAS number	50924-49-7

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Inosine-5'-monophosphate dehydrogenase 1	MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVD...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682