Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. Oral atropine is only available in combination products.[A251660,L42840] Atropine is a competitive, reversible antagonist of muscarinic receptors that blocks the effects of acetylcholine and other choline esters.[A251660,L42815,L42825,L42835] It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes.[A251660] Atropine is a relatively inexpensive drug and is included in the World Health Organization List of Essential Medicines.[A251675]
Synonyms
Atropine
Atropine sulfate anhydrous
dl-tropyltropate
dl-Hyoscyamine
Tropine tropate
Atropina
(±)-hyoscyamine
Atropinum
Atropin
Atropine hydrochloride
(±)-atropine
Atropine sulfate
Brand Names
Diphenoxylate hydrochloride and atropine sulfate
PB Hyos
B-Donna
Atropine Sulfate Inj 0.4mg/0.5ml
Motofen
Atropine Injection Bp 0.6mg/ml
Phenobarbital With Belladonna Alkaloids
Donnatal
Servira
Atropine Sulphate 1% - Liq Oph
N/a
Phenobarbital with Belladonna Alkaloids - Grape
Atropine Care
Odan-atropine
Alcon Atropine
Vitetal
Diphenoxylate Hcl and Atropine Sulfate
Enlon-Plus
Atropine Sulfate Inj 0.4mg/ml
Atropine Sulfate Injection USP
Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide
ATNAA atropine and pralidoxime chloride Auto-Injector
Diban Cap
Quadrapax
Re-PB Hyos
Donnatal Tab
Me-PB-Hyos
Atropine Sulfate
Isopto Atropine
Re-PB Hyos Elixir
DuoDote
Atropine Injection Bp 0.4mg/ml
Phenohytro
Enlon Plus
Donnatal Extentabs Srt
Belladonna Alkaloids with Phenobartbital
Urised
Atropine Ont 1%
Atropine Sulfate Inj 0.3mg/ml
Donnatal Extentabs
R.O.-atropine
Atropine
Donnagel Liq
Lomotil
Atropine Injection BP
Atropisol Oph Soln 1%
Se-donna Pb Hyos
Atropine Sulfate Inj 0.6mg/ml
Phenobarbital with Belladonna Alkaloids
Atropine sulfate
Donnatal Elixir
Minims Atropine Sulphate
ATROPEN Auto-Injector
Atropine Sulfate Injection
Atropine Sulfate Inj 1mg/ml
Phenobarbital with Belladonna Alkaloids - Mint
Atropine 1%
Atropisol
Indication
The intravenous, intramuscular, subcutaneous, intraosseous and endotracheal use of atropine is indicated for the temporary blockade of severe or life-threatening muscarinic effects.[L42815,L42835] The intramuscular use of atropine in the form of a pen injector is indicated for the treatment of poisoning by susceptible organophosphorus nerve agents having cholinesterase activity as well as organophosphorus or carbamate insecticides in adult and pediatric patients.[L42825] The ophthalmic use of atropine is indicated for mydriasis, cycloplegia, and penalization of the healthy eye in the treatment of amblyopia.[L42830] In combination with difenoxin or diphenoxylate (tablets for oral use), atropine is indicated as adjunctive therapy in the management of acute nonspecific diarrhea.[L42840,L42865]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
