SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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120 entries where SER is found as a standalone ligand52 entries where SER is covalently linked to polymer or other heterogen groups 238,793 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	Serine (S)-Serine Serina (S)-2-Amino-3-hydroxypropanoic acid Serinum Ser L-Serine alpha-Amino-beta-hydroxypropionic acid beta-Hydroxyalanine
Brand Names	HepatAmine Aminosyn II 7% With 10% Dextrose Aminosyn II 7% With 50% Dextrose Vamin 18 Electrolyte-free 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn-PF 7% Primene Aminosyn II 5% Inj Premasol - sulfite-free (Amino Acid) Aminosyn 7% Aminosyn 3.5% M Olimel 4.4% E Aminosyn 10% W Electrolytes Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 7.6% Novamine Periolimel 2.5% E Smofkabiven Electrolyte Free Hepatasol Aminosyn II 8.5% Injection 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn HF Aminosyn II with Electrolytes Smofkabiven Synthamin FreAmine HBC 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinisol Aminosyn II 10% With Electrolytes Aminosyn II 7% Injection 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex TrophAmine Clinimix E Aminosyn II 7% M In 10% Dextrose(dual Chamber) Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Olimel 7.6% E 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Olimel 5.7% Kabiven 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn Sulfite Free 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn 5% Olimel 3.3% E Aminosyn-PF 10% Nutrineal Pd4 Plenamine Aminosyn II and Dextrose Primene 10%-liq IV Olimel 5.7% E 20% Prosol 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn-PF Aminosyn II in Dextrose Aminosyn 8.5% Injection With Electrolytes Travasol Essepna Clinimix ProcalAmine FreAmine III 8.5% Freamine III Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn II In Dextrose Injection Aminosyn Aminosyn II 8.5% With 50% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose RenAmin Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) ProSol Aminosyn 8.5% 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Renamin (amino Acids) Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Vamin N Olimel 4.4% Perikabiven 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Primene 10% 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Smofkabiven Extra Nitrogen
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6857581, 5951
ChEMBL	CHEMBL11298
ChEBI	CHEBI:33384, CHEBI:17115
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01