SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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120 entries where SER is found as a standalone ligand52 entries where SER is covalently linked to polymer or other heterogen groups 235,709 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	Ser Serina Serine alpha-Amino-beta-hydroxypropionic acid L-Serine beta-Hydroxyalanine (S)-Serine Serinum (S)-2-Amino-3-hydroxypropanoic acid
Brand Names	Smofkabiven Extra Nitrogen 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 3.3% E 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II with Electrolytes TrophAmine Clinimix Aminosyn Sulfite Free Synthamin 20% Prosol Aminosyn II 7% Injection Smofkabiven Perikabiven Renamin (amino Acids) Injection 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Premasol - sulfite-free (Amino Acid) Aminosyn II 8.5% Injection Aminosyn 5% ProSol Essepna Aminosyn 8.5% Injection With Electrolytes Clinimix E Aminosyn II 7% With 50% Dextrose 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn-PF 7% Olimel 7.6% Olimel 5.7% E Aminosyn-PF 10% Primene 10%-liq IV FreAmine III Novamine Smofkabiven Electrolyte Free 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Hepatasol Plenamine Smofkabiven Peripheral Aminosyn II In Dextrose Injection RenAmin 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn II 5% Inj ProcalAmine Aminosyn 8.5% Aminosyn II and Dextrose Aminosyn 10% W Electrolytes Aminosyn II in Dextrose Primene FreAmine HBC Travasol Aminosyn II 7% M In 10% Dextrose(dual Chamber) Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Nutrineal Pd4 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn-PF Vamin N Kabiven Aminosyn HF Olimel 7.6% E 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Olimel 4.4% Aminosyn II Aminosyn II 8.5% With 50% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn 8.5% Freamine III Aminosyn II 7% With 10% Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn II 10% With Electrolytes Aminosyn 3.5% M Clinisol HepatAmine Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Smofkabiven Extra Nitrogen Electrolyte Free Primene 10% Olimel 5.7% Vamin 18 Electrolyte-free 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Periolimel 2.5% E Aminosyn 7% 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Olimel 4.4% E
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6857581, 5951
ChEMBL	CHEMBL11298
ChEBI	CHEBI:17115, CHEBI:33384
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01