SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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114 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 231,224 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	Ser L-Serine Serine (S)-2-Amino-3-hydroxypropanoic acid alpha-Amino-beta-hydroxypropionic acid Serina (S)-Serine Serinum beta-Hydroxyalanine
Brand Names	Travasol Aminosyn II 7% M In 10% Dextrose(dual Chamber) Olimel 4.4% E Plenamine 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Periolimel 2.5% E Olimel 5.7% 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose ProSol Primene 10% ProcalAmine Smofkabiven 8.5% Freamine III Olimel 4.4% TrophAmine Vamin N 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Olimel 7.6% E Olimel 7.6% Aminosyn II 7% With 50% Dextrose FreAmine HBC Aminosyn II with Electrolytes in Dextrose with Calcium Primene 10%-liq IV Clinisol Smofkabiven Extra Nitrogen Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) RenAmin 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Renamin (amino Acids) Injection FreAmine III Olimel 3.3% E 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn Smofkabiven Electrolyte Free HepatAmine 20% Prosol Aminosyn-PF 10% Clinimix E Kabiven Clinimix Aminosyn II in Dextrose Novamine Aminosyn II and Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn Sulfite Free Aminosyn II 5% Inj Aminosyn-PF Aminosyn 3.5% M Vamin 18 Electrolyte-free Aminosyn HF Aminosyn-PF 7% Aminosyn 5% Olimel 5.7% E Aminosyn II Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn II In Dextrose Injection 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Essepna Premasol - sulfite-free (Amino Acid) 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn 8.5% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Perikabiven Aminosyn II 8.5% Injection Aminosyn 10% W Electrolytes Nutrineal Pd4 Synthamin 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II 8.5% With 50% Dextrose Primene 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Smofkabiven Peripheral Aminosyn II 7% Injection Hepatasol Aminosyn II 7% With 10% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn II 10% With Electrolytes Aminosyn 7% Aminosyn 8.5% Injection With Electrolytes Aminosyn II with Electrolytes 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5951, 6857581
ChEMBL	CHEMBL11298
ChEBI	CHEBI:17115, CHEBI:33384
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01