SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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120 entries where SER is found as a standalone ligand52 entries where SER is covalently linked to polymer or other heterogen groups 239,092 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	Serina beta-Hydroxyalanine Serinum (S)-Serine Ser (S)-2-Amino-3-hydroxypropanoic acid alpha-Amino-beta-hydroxypropionic acid Serine L-Serine
Brand Names	Aminosyn-PF 10% Vamin N Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn II Olimel 4.4% Travasol Olimel 5.7% E Aminosyn HF Aminosyn 8.5% 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn II in Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex. 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Olimel 5.7% Aminosyn II 8.5% Injection 20% Prosol Aminosyn II 8.5% With 50% Dextrose Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn-PF ProSol Renamin (amino Acids) Injection Premasol - sulfite-free (Amino Acid) Nutrineal Pd4 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn 10% W Electrolytes TrophAmine Aminosyn II 10% With Electrolytes Essepna Aminosyn II with Electrolytes Clinimix E 8.5% Freamine III Primene 10%-liq IV Kabiven Synthamin 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn Sulfite Free Smofkabiven RenAmin Aminosyn 7% Smofkabiven Extra Nitrogen Olimel 4.4% E 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Smofkabiven Electrolyte Free Primene 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Novamine Olimel 7.6% E HepatAmine Aminosyn Aminosyn II and Dextrose Aminosyn 8.5% Injection With Electrolytes 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Aminosyn 5% Aminosyn 3.5% M 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn-PF 7% ProcalAmine 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Perikabiven Aminosyn II 5% Inj Aminosyn II 7% Injection Vamin 18 Electrolyte-free Aminosyn II 7% With 50% Dextrose Olimel 7.6% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. FreAmine III 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Periolimel 2.5% E Aminosyn II In Dextrose Injection 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Olimel 3.3% E Aminosyn II 7% M In 10% Dextrose(dual Chamber) Aminosyn II with Electrolytes in Dextrose with Calcium Hepatasol FreAmine HBC Primene 10% Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn II 7% With 10% Dextrose Clinisol Plenamine
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5951, 6857581
ChEMBL	CHEMBL11298
ChEBI	CHEBI:17115, CHEBI:33384
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01