Tazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. It is combined with [Piperacillin] and [Ceftolozane] for the treatment of a variety of bacterial infections. Piperacillin-tazobactam was initially approved by the FDA in 1994, and ceftolozane-tazobactam was approved by the FDA in 2014[FDA label], providing wider antibacterial coverage for gram-negative infections. In June 2019, ceftolozane-tazobactam was approved by the FDA for treating hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia, which are significant causes of morbidity and mortality in hospitalized patients.[L6673]
Synonyms
Tazobactam
Tazobactamum
Tazobactam sodium
Brand Names
Piperacillin Sodium / Tazobactam Sodium
PIPERACILLIN SODIUM and TAZOBACTAM SODIUM
Zerbaxa
Zosyn
Zosyn in Galaxy Containers
Zosyn Pharmacy Bulk Package
Jamp-pip/taz
Piperacillin and Tazobactam for Injection
Tazocin Pws IV 3g Piperacillin-.375g Tazobac
Piperacillin/tazobactam for Injection
Tazocin Pws IV 2g Piperacillin-.25g Tazobac.
Vpi-piperacillin and Tazobactam for Injection
Piperacillin, Tazobactam
Tazocin
Piperacillin and Tazobactam
Piperacillin / Tazobactam Powder for Injection
Tazocin Pws IV 4g Piperacillin-.5g Tazobac.
Indication
Tazobactam is used in combination with piperacillin or ceftolozane to broaden the spectrum of piperacillin antibacterial action, treating susceptible infections. As with any other antibiotic, tazobactam should only be used for infections that are either proven or strongly suspected to be susceptible to the tazobactam containing drug. **Tazobactam-piperacillin** When combined with piperacillin, it is used to treat a variety of infections, including those caused by aerobic and facultative gram-positive and gram-negative bacteria, in addition to gram-positive and gram-negative anaerobes. Some examples of infections treated with piperacillin-tazobactam include cellulitis, diabetic foot infections, appendicitis, and postpartum endometritis infections.[L4417] Certain gram-negative bacilli infections with beta-lactamase producing organisms cannot be treated with piperacillin-tazobactam, due to a gene mutation conferring antibiotic resistance.[A179266] **Tazobactam-ceftolozane** Tazobactam is used in combination with [ceftolozane] for the treatment of infections caused by designated susceptible microorganisms in adult and pediatric patients:[L41618] - Complicated Intra-abdominal Infections (cIAI), used in combination with [metronidazole] - Complicated Urinary Tract Infections (cUTI), including pyelonephritis - Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia (HABP/VABP)
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
