TE4

Tetracaine

Created:	2014-02-11
Last modified:	2021-03-01

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6 entries where TE4 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	43
Chiral Atom Count	0
Bond Count	43
Aromatic Bond Count	6

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Chemical Component Summary
Name	Tetracaine
Synonyms	2-(dimethylamino)ethyl 4-(butylamino)benzoate
Systematic Name (OpenEye OEToolkits)	2-(dimethylamino)ethyl 4-(butylamino)benzoate
Formula	C₁₅ H₂₄ N₂ O₂
Molecular Weight	264.363
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	O=C(OCCN(C)C)c1ccc(NCCCC)cc1
SMILES	CACTVS	3.385	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
SMILES	OpenEye OEToolkits	1.7.6	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
Canonical SMILES	CACTVS	3.385	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
Canonical SMILES	OpenEye OEToolkits	1.7.6	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InChI	InChI	1.03	InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
InChIKey	InChI	1.03	GKCBAIGFKIBETG-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB09085
Name	Tetracaine
Groups	vet_approved approved
Description	Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.
Synonyms	2-(Dimethylamino)ethyl p-(butylamino)benzoate Tetracaine p-Butylaminobenzoyl-2-dimethylaminoethanol Medihaler-Tetracaine Metraspray Tetracaína Diäthylaminoäthanol ester der p-butylaminobenzösäure Tetracaine hydrochloride p-(butylamino)benzoic acid β-(dimethylamino)ethyl ester Tetracaine HCl Amethocaine HCl Tétracaïne Dicaine 2-(dimethylamino)ethyl 4-(butylamino)benzoate Amethocaine
Brand Names	T.R.U.E. Test Thin-Layer Rapid Use Patch Test Denti-Care Denti-Freeze Topical Anesthetic Strawberry Pain Prescriptives Topical Analgesic LL Super T Cutiecaine Blue Gel Anesthetic NeuroMed Topical Analgesic LA BLT Skin Cream Painless Tattoo 3 Minims Tetracaine Hydrochloride Ritual Tattoo Reveal Foam Altacaine Cetacaine Spray Dermacaine-R Inderma MD Denti-Care Denti-Freeze Topical Anesthetic Bubblegum Zap Topical Anesthetic Spray Aerosol Tetragel Punch Topical Analgesic Tetracaine Hydrochloride Spinal Anesthesia Tray Pontocaine Niphanoid Burn Cream Cetacaine Anesthetic Penichillin Burn Solution Cream Zap Liquid Spinal Anaesthesia Tray Synera Eclipse Topical Analgesic LL Kovanaze One Touch Advanced Topical Anesthetic Bubble Gum Cetacaine Liquid Denti-care Topical Anesthetic Gel Supracaine Aem 754mg/65gm Endospray Lidocaine 7% / Tetracaine 7% Ritual Tattoo Lidocaine and Tetracaine Benzocaine 20% / Lidocaine 10% / Tetracaine 10% Tetracaine Blt 3 Henry Schein Topical Anesthetic Gel Tetracaine2 Sj3 Ndc 72934- 5010-4 Benzocaine 20% / Lidocaine 8% / Tetracaine 4%. One Touch Topical Anesthetic Gel Denti-Care Denti-Freeze Topical Anesthetic Raspberry Zap Topical Anesthetic Spray Zap Topical Anesthetic Gel Pontocaine 5 mg/ml Tetramex Denticare Pro-freeze Panocaine Gel Lidocaine 23% / Tetracaine 7% Viractin Moisturizing Cream Comfortox Tetracaine Tetracaine HCL NeuroMed LA Plush anesthetics T Pro Plus One Touch Advanced Topical Anesthetic Strawberry Ice Viractin Gel TetraVisc One Touch Advanced Topical Anesthetic Gel Cool Mint Pliaglis Exactacain Topical Anesthetic One Touch Advanced Topical Anesthetic Cherry Supracaine Aerosol 11.6mg/gm Tetracaine (Base) FranklyNumb 3 tetraVIV Advanced Cold Sore Care Pontocaine Dps 0.5% TetraVisc Forte Ametop Gel 4% Denti-Care Denti-Freeze Topical Anesthetic Mint Denti-care Topical Anesthetic Liquid Spray Blockaid Pontocaine Pws Inj 20mg/amp Cetacaine Topical Anesthetic Numfast Tetracaine Green Denti-Care Denti-Freeze Topical Anesthetic Cherry
Indication	Ophthalmic tetracaine is indicated for the for procedures requiring a rapid and short- acting topical ophthalmic anesthetic. The combination lidocaine and tetracaine patch is indicated for local dermal analgesia for superficial dermatological procedures and superficial venous access. The combination lidocaine and tetracaine cream is intended to provide topical local analgesia for superficial dermatological procedures.
Categories	Acids, Carbocyclic Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Aminobenzoates Anesthetics Anesthetics for Topical Use Anesthetics, General Anesthetics, Local Antipruritics and Local Anesthetics Antipruritics, Incl. Antihistamines, Anesthetics, Etc. Benzene Derivatives Benzoates Central Nervous System Agents Central Nervous System Depressants Dental Agents Dermatologicals Esters of Aminobenzoic Acid Local Anesthesia Local Anesthetics (Ester) Methemoglobinemia Associated Agents Nervous System Ophthalmologicals para-Aminobenzoates Peripheral Nervous System Agents Sensory Organs Sensory System Agents Vasoprotectives
ATC-Code	C05AD02 N01BA03 D04AB06 N01BA53 S01HA03
CAS number	94-24-6

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Ryanodine receptor 1	MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEP...	unknown	modulator
Sodium channel protein type 10 subunit alpha	MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEK...	unknown	inhibitor
Ryanodine receptor 2	MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLE...	unknown	modulator
Voltage-gated sodium channel alpha subunit	MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPK...	unknown	blocker

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682