Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
1,2,3-propanetrioltrinitrate
Glycerol, nitric acid triester
Nitroglycerin
Glyceroltrinitrat
Trinitroglycerin
Nitroglicerina
Glycerin trinitrate
Glyceryl trinitrate
Nitroglycerol
Trinitrine
Glycerol trinitrate
Glyceroli trinitratis
NG
1,2,3-propanetriyl nitrate
Propane-1,2,3-triyl trinitrate
Nitroglycerine
Trinitroglycerol
Nitromed
Brand Names
Mylan-nitro Sublingual Spray
Nitroglycerin SR
Nitrolingual Spray 0.4mg/eam
Deluxe Dental Emergency Kit
Nitro-dur
Trinipatch 0.4
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Mylan-nitro Patch 0.8
Nitro-dur 0.6
Nitro-dur 0.2
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Nitro-dur 0.8
Transderm-nitro 0.4
Tridil Injection 5mg/ml
Transderm-nitro 0.6
Nitroglycerin Lingual
NitroMist
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Trinipatch 0.2
Nitroglycerin Transdermal System
Basic Dental Emergency Kit
Apo-nitroglycerin
Rectiv
Transderm-nitro 0.8
Nitroglycerin in Dextrose
Nitrostat
Trinipatch 0.6
Nitronal
Nitrolingual Pumpspray
Nitroglycerin Inj 5mg/ml
Nitroglycerin Slocaps
Nitrolingual
Nitroglycerin ER
Nitroglycerin In Dextrose
Nitro-Time
Mylan-nitro Patch 0.2
Gonitro
Nitroject
Nitro-dur 0.4
Nitroglycerin
Nitro-time
Nitroglycerin Transdermal Delivery System
Rho-nitro Pumpspray
Mylan-nitro Patch 0.4
Transderm Nitro
Nitroject Inj 1mg/ml
Minitran
Nitrogard-SR Tab 1mg
Nitrol
Nitrong SR Srt 2.6mg
Transderm-nitro 0.2
Minitran - Patch Trd 72mg/26.6 Sq Cm
Nitroglycerin Transdermal Infusion System
Mylan-nitro Patch 0.6
Nitro-bid
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Nitroglycerin Injection USP
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
