Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
Glycerol trinitrate
Glycerol, nitric acid triester
Nitromed
Glyceroltrinitrat
Trinitroglycerin
NG
Glyceroli trinitratis
Glyceryl trinitrate
Nitroglycerin
Nitroglycerol
Trinitrine
Propane-1,2,3-triyl trinitrate
1,2,3-propanetriyl nitrate
1,2,3-propanetrioltrinitrate
Nitroglycerine
Nitroglicerina
Trinitroglycerol
Glycerin trinitrate
Brand Names
Mylan-nitro Patch 0.4
Nitro-dur 0.4
Nitro-dur 0.2
Nitroglycerin Transdermal Infusion System
Nitroject Inj 1mg/ml
Deluxe Dental Emergency Kit
Mylan-nitro Patch 0.6
Nitroject
Nitrol
Rho-nitro Pumpspray
Gonitro
Nitrolingual
Nitroglycerin Inj 5mg/ml
Minitran - Patch Trd 72mg/26.6 Sq Cm
Tridil Injection 5mg/ml
Mylan-nitro Patch 0.8
Nitroglycerin in Dextrose
Trinipatch 0.2
Nitro-Time
Nitro-bid
Nitro-dur 0.8
Mylan-nitro Patch 0.2
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Nitroglycerin
Nitrong SR Srt 2.6mg
Transderm-nitro 0.4
Trinipatch 0.4
Nitrostat
Nitroglycerin In Dextrose
Nitro-dur
Nitrolingual Pumpspray
Nitronal
Transderm-nitro 0.2
Minitran
Nitroglycerin Injection USP
Nitrolingual Spray 0.4mg/eam
Nitroglycerin Transdermal System
Trinipatch 0.6
Basic Dental Emergency Kit
Nitroglycerin Lingual
Nitro-dur 0.6
Apo-nitroglycerin
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Mylan-nitro Sublingual Spray
Transderm-nitro 0.8
Nitrogard-SR Tab 1mg
Nitroglycerin Slocaps
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Transderm Nitro
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Nitroglycerin Transdermal Delivery System
Nitroglycerin SR
NitroMist
Rectiv
Nitro-time
Nitroglycerin ER
Transderm-nitro 0.6
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
