Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
NG
Nitroglicerina
Trinitroglycerin
1,2,3-propanetriyl nitrate
Glycerin trinitrate
Nitroglycerine
Nitromed
Trinitrine
Trinitroglycerol
Glycerol, nitric acid triester
Glycerol trinitrate
1,2,3-propanetrioltrinitrate
Glyceryl trinitrate
Propane-1,2,3-triyl trinitrate
Glyceroltrinitrat
Glyceroli trinitratis
Nitroglycerol
Nitroglycerin
Brand Names
Nitroglycerin In Dextrose
Basic Dental Emergency Kit
Nitroject Inj 1mg/ml
Deluxe Dental Emergency Kit
Nitro-bid
Nitro-dur
Transderm-nitro 0.8
Nitro-dur 0.6
Minitran
Mylan-nitro Patch 0.6
Mylan-nitro Sublingual Spray
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Nitrong SR Srt 2.6mg
Nitroglycerin Transdermal Infusion System
Nitro-dur 0.4
Nitroject
NitroMist
Nitro-time
Nitro-dur 0.2
Nitroglycerin
Mylan-nitro Patch 0.2
Rho-nitro Pumpspray
Nitroglycerin Slocaps
Trinipatch 0.6
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Nitro-Time
Transderm Nitro
Nitroglycerin Transdermal System
Gonitro
Nitrolingual Pumpspray
Nitroglycerin in Dextrose
Nitro-dur 0.8
Nitrol
Transderm-nitro 0.2
Mylan-nitro Patch 0.8
Tridil Injection 5mg/ml
Trinipatch 0.4
Apo-nitroglycerin
Trinipatch 0.2
Minitran - Patch Trd 72mg/26.6 Sq Cm
Nitrolingual Spray 0.4mg/eam
Mylan-nitro Patch 0.4
Nitroglycerin SR
Transderm-nitro 0.6
Nitroglycerin Transdermal Delivery System
Nitronal
Transderm-nitro 0.4
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Rectiv
Nitroglycerin ER
Nitroglycerin Lingual
Nitroglycerin Injection USP
Nitrostat
Nitroglycerin Inj 5mg/ml
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Nitrolingual
Nitrogard-SR Tab 1mg
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
