Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
Glycerol trinitrate
Nitroglycerol
Nitromed
Nitroglycerine
Trinitrine
1,2,3-propanetrioltrinitrate
Glyceroltrinitrat
Glycerin trinitrate
Trinitroglycerin
Trinitroglycerol
Glyceroli trinitratis
1,2,3-propanetriyl nitrate
NG
Glyceryl trinitrate
Glycerol, nitric acid triester
Nitroglycerin
Propane-1,2,3-triyl trinitrate
Nitroglicerina
Brand Names
Transderm-nitro 0.4
Nitroject Inj 1mg/ml
Nitroglycerin SR
Nitrong SR Srt 2.6mg
Nitro-dur 0.2
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Mylan-nitro Patch 0.6
Nitroject
Transderm Nitro
Transderm-nitro 0.2
Nitroglycerin Slocaps
Transderm-nitro 0.8
Trinipatch 0.4
Mylan-nitro Patch 0.2
Nitro-Time
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Gonitro
Trinipatch 0.2
Nitrolingual Pumpspray
Trinipatch 0.6
Nitroglycerin Lingual
Nitro-time
Mylan-nitro Patch 0.4
Nitrolingual
Nitrolingual Spray 0.4mg/eam
Minitran - Patch Trd 72mg/26.6 Sq Cm
Rectiv
Tridil Injection 5mg/ml
Nitro-bid
Nitrogard-SR Tab 1mg
Nitroglycerin
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Nitroglycerin In Dextrose
Nitrol
Deluxe Dental Emergency Kit
Nitronal
Nitrostat
Transderm-nitro 0.6
Basic Dental Emergency Kit
Mylan-nitro Patch 0.8
Nitroglycerin ER
Nitroglycerin Transdermal Infusion System
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Nitroglycerin Inj 5mg/ml
Nitroglycerin in Dextrose
Nitroglycerin Injection USP
Nitroglycerin Transdermal Delivery System
Rho-nitro Pumpspray
Nitro-dur
NitroMist
Mylan-nitro Sublingual Spray
Nitro-dur 0.8
Nitro-dur 0.4
Apo-nitroglycerin
Nitro-dur 0.6
Minitran
Nitroglycerin Transdermal System
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
