Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival.[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.[T707]
Sulfamethoxazole and Trimethoprim (Double Strength)
sulfamethoxazole-trimethoprim (SMZ)
Primsol
Septra Pediatric Suspension
Trimethoprim sulfate and Polymyxin B sulfate
Polymyxin B Sulfate and Trimethoprim
Bactrim Roche Suspension Paediatric
Proloprim 200 Tab 200mg
Sulfamethox-TMP DS
Coptin Oral Suspension
Sulfamethoxazole and Trimethoprim
SULFAMETHOXAZOLE AND TRIMETHOPRIM double strength
Bactrim Roche Inj
Apo-sulfatrim Oral Suspension
Roubac Tab 160/800
PMS-polytrimethoprim
Sandoz Polytrimethoprim
Protrin Tab
Sulfamethoxazole and Trimethoprim Double Strength
Sulfamethoxazole and Trimethoprim Injection, BP
Roubac Tab 80/400
Coptin Tab
Sulfatrim Pediatric
PrimSol
Sulfamethoxazole and Trimethoprim Tablets
Septra Injection
Bactrim
Sulfatrim
Teva-trimel
Nu-cotrimox-DS Tab 800/160mg
Nu-cotrimox Tab 400/80mg
Septra DS Tablets
Protrin Df Tab
Sulfamethoxazole and Trimethoprim for Injection, USP
Riva-sep DS
Sulfameth/Trimeth-DS
Teva-trimel DS
Trimethoprim
Polytrim Ophthalmic Solution
Septra Grape
Trisulfa DS Tab
Trimethoprim Tablets
Bactrim DS Roche Tab
Sulfamethoxazole and Trimethoprim DS
Nu-cotrimox Sus 40/8mg/ml
Septra
SulfatrimTM Pediatric Suspension
Trisulfa Tab
TRIMPEX trimethoprim hydrochloride
Proloprim
Polytrim
Polymyxin B Sulfate and Trimethoprim Sulfate
Septra DS
Trisulfa S Suspension
Bactrim DS
Indication
As a monotherapy, trimethoprim is indicated for the treatment of acute episodes of uncomplicated urinary tract infections caused by susceptible bacteria, including _E. coli._, _K. pneumoniae_, _Enterobacter spp._, _P. mirabilis_, and coagulase-negative _Staphylococcus_ species.[L11893,L11890] In various formulations in combination with [sulfamethoxazole], trimethoprim is indicated for the following infections caused by bacteria with documented susceptibility: urinary tract infections, acute otitis media in pediatric patients (when clinically indicated), acute exacerbations of chronic bronchitis in adults, enteritis caused by susceptible _Shigella_, prophylaxis and treatment of _Pneumocystis jiroveci_ pneumonia, and travelers' diarrhea caused by enterotoxigenic _E. coli_.[L11830,L11863] Trimethoprim is available as an ophthalmic solution in combination with [polymyxin B] for the treatment of acute bacterial conjunctivitis, blepharitis, and blepharoconjunctivitis caused by susceptible bacteria.[L11887]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
