Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms.[L11512] It is one of the most common skin and mucous membrane antiseptic agents in use today.[A190417] The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two biguanide groups joined by a central hexamethylene chain.[A190453] Topical chlorhexidine for disinfection, as well as oral rinses for dental use, carries activity against a broad range of pathogens including bacteria, yeasts, and viruses.[L11518,L11512,A190453] Chlorhexidine was developed in the UK by Imperial Chemical Industries in the early 1950s[A190474] and was introduced to the US in the 1970s.[L11572] The FDA withdrew its approval for the use of chlorhexidine gluconate topical tincture 0.5%, due to a significant number of reports concerning chemical and thermal burns associated with the use of this product.[L43942,L44027] Other formulations of chlorhexidine continue to be available.
QCare Rx Petite Oral Cleansing and Suctioning System
Rugby Antiseptic Skin Cleanser
Bei Ling Tong Bao Er Zheng Yuan Antibacterial Creams
Pre and Post Sx Pouch
Scrub, Scrub-Stat
Foam Care Chg Surgical Hand Scrub
Foaming Chlorhexidine Gluconate
Chlorhexidine Gluconate 0.12% Oral Rinse, USP
Gum Paroex
Germi-stat Prep Gel
X-pur Chlorhexidine
3M Avagard
Hibitane Skin Cleanser Liq 4%
Bactoshield
Germi-stat 2% Foaming Liquid
Ostar Antimicrobial Hand Soap 2% - Liquid
Dr. Luke Molluscum Wart Remover
NuSurgePak Surgical Prep/CarePak
Stanhexidine 4% With Isopropyl Alcohol 4%
Stanhexidine Aqueous 2% With 4% Isopropyl Alcohol
Soluprep Qd Wipe
Flamazine C
Hand Sanitizer Gel Biokaab
Protective Hand
Motherwort Herb Feminine Antibacterial Gels
Indication
Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures.[L11518,L11521,L11527,L11533] Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis[L11512] and a slow-release "chip" which is inserted into periodontal pockets and is indicated for the reduction of pocket depth in adult patients with periodontitis as an adjunct therapy to dental scaling and root planing procedures.[L11536]
Categories
Alimentary Tract and Metabolism
Amidines
Anti-Infective Agents
Anti-Infective Agents, Local
Antiinfectives and Antiseptics for Local Oral Treatment
Antiseptics and Disinfectants
Biguanides
Biguanides and Amidines
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
