Impact of PDB Structures on Anti-Cancer Drug Approvals

12/02 

A new flyer highlights the Impact of PDB Structures on US FDA Anti-Cancer Drug Approvals (2010-2023) (PDF).

For more, see

• Impact of structural biology and the Protein Data Bank on US FDA new drug approvals of low molecular weight antineoplastic agents 2019–2023
  (2024) Oncogene 43: 2229-2243 doi: 10.1038/s41388-024-03077-2
• Impact of the Protein Data Bank on antineoplastic approvals
  (2020) Drug Discovery Today 25:837-850 doi: 10.1016/j.drudis.2020.02.002

Impact of PDB Structures on US FDA Anti-Cancer Drug Approvals (2010-2023)

News Index

• 11/11 PDB-101 Focus: Peak Performance

• 11/06 Register Now for Webinar: Exploring Integrative Structures with RCSB.org

• 11/06 Education Corner: Cambridge Structural Database

• 11/04 Powering a New Era in Structural Biology

• 11/02 Register Now for Webinar: Exploring the Workhorses of Biotechnology

• 10/30 Coming Soon: Remediation of Metalloprotein-containing PDB Entries and CCDs

• 10/28 Watch Molecules in Motion

• 10/21 Explore Green Fluorescent Protein

• 10/19 Happy Birthday, PDB!

• 10/16 Happy Birthday, Irving Geis

• 10/14 PDB-101 Focus: Peak Performance

• 10/08 Explore Structural Biology with CSMs

• 10/07 Register for the Nov 24 Virtual Office Hour on Exploring CSMs at RCSB.org

• 10/06 Fall Newsletter Published

• 10/05 Structural Biology and Nobel Prizes

• 10/02 Register for the Oct 30 Virtual Office Hour on Structure Summary Pages

• 10/01 Video: Vitamin A and Vision

• 09/30 Explore Inktober SciArt images

• 09/30 Register Now for Webinar: Exploring the Workhorses of Biotechnology

• 09/28 Watch the Pairwise Alignment Tool Office Hour

• 09/23 wwPDB News: Introducing the first 3DEM Model-Map percentile slider to the wwPDB validation report

• 09/23 Browse Protein Structure Prediction at PDB-101

• 09/23 Register for the Sept 25 Virtual Office Hour on PDB Policies

• 09/22 wwPDB News: MolViewSpec: describe, share, and reproduce Mol* molecular scenes

• 09/16 Register Now for Webinar: Exploring Integrative Structures with RCSB.org

• 09/15 PDB-101 Focus: Peak Performance

• 09/08 RCSB.org is Powered by AWS

• 09/02 Register for the Oct 30 Virtual Office Hour on Structure Summary Pages

• 09/02 Video: Caffeine and Adenosine

• 08/26 PDB-101: Global Health

• 08/25 Register Now for Webinar: Searching the PDB for high-quality ligand-bound structures

• 08/21 Poster Prize Awarded at ISMB/ECCB 2025

• 08/19 Announcement: Ligand Expo To Be Retired in 2025

• 08/19 PDB-101 Focus: Peak Performance

• 08/18 wwPDB News: Paper Published: 3DEM Structure-Map Validation Recommendations

• 08/14 Poster Prize Awarded at ACA 2025

• 08/12 Paper Published: PDB-IHM

• 08/11 Register for the Sept 25 Virtual Office Hour on PDB Policies

• 08/05 Register for the Aug 11 Virtual Office Hour on Pairwise Alignment

• 08/05 Paper Published: rcsb-api

• 08/01 August 2 is National Coloring Book Day

• 07/29 Register Now for Webinar: Searching the PDB for high-quality ligand-bound structures

• 07/29 Celebrate World RNA Day on August 1 with Eterna

• 07/22 Prepare Depositions Using pdb_extract

• 07/22 PDB-101 Focus: Peak Performance

• 07/18 Meet the RCSB PDB at ACA 75

• 07/15 wwPDB News: Transitioning to PDBx/mmCIF and Extended PDB IDs

• 07/15 Color the Diverse 3D Shapes Studied by Crystallographers

• 07/08 Summer Newsletter Published

• 07/03 Register for the Aug 11 Virtual Office Hour on Pairwise Alignment

• 07/01 Download New Poster: CSMs and PDB Structures

• 07/01 Watch the Webinar: Python For Cheminformatics-Driven Molecular Docking

• 06/25 wwPDB News: Extension to EMDB Accession Codes

• 06/24 Python Toolkit for Accessing RCSB.org Search and Data APIs

• 06/19 Watch: Deep Dive into Computed Structure Model Exploration at RCSB.org

• 06/16 Register for the ACA Workshop on PDB Deposition

• 06/13 Download an image of H5N1

• 06/10 PDB-101 Focus: Peak Performance

• 06/09 Watch the Sequence Annotations Viewer Office Hour

• 06/03 Electron Density Maps and Coefficient Files

• 05/28 Explore Integrative Structures at RCSB.org

• 05/26 Annual Report Published

• 05/22 Register Now for Tutorial: Introduction to Molecular Animation

• 05/20 Video: Immunology and Cancer

• 05/19 Announcement: Ligand Expo To Be Retired in 2025

• 05/19 Access Computed Structure Model Annotations

• 05/16 PDB-101 Focus: Peak Performance

• 05/13 Paper Published: A new chapter for Molecule of the Month

• 05/12 Education Corner: BASIL, RCSB Protein Data Bank, and the NSF

• 05/06 Watch the Webinar: Seeing Bird Flu in 3D

• 05/06 wwPDB News: Poster Prize Awarded at ASBMB

• 05/04 Commemorating 75 Years of Discovery and Innovation at the NSF

• 05/01 Toggle to "Opt-in" to Access Computed Structure Models Alongside PDB Data

• 04/28 Watch the Webinar: Streamlining Access to RCSB PDB APIs with Python

• 04/25 Education Corner: Paper Nucleic Acid Models for Hands-on Education

• 04/22 wwPDB Validation Reports Accessible via API

• 04/22 Celebrate DNA Day on April 25

• 04/18 April 22 is Earth Day

• 04/16 wwPDB News: Download Snapshots of the PDB Core Archive via HTTPS, SYNC, RSYNC, or FTP

• 04/15 Introducing Extended PDB IDs at RCSB.org

• 04/15 Paper Published: Visualizing and analyzing 3D biomolecular structures using Mol*

• 04/11 Meet RCSB PDB at ASBMB

• 04/08 Sequence Annotations Viewer: Geometry Validation

• 04/07 Spring Newsletter Published

• 04/03 PDB-101 Focus: Peak Performance

• 04/01 Paper Published: PDB and a transformative impact on science and society

• 03/27 Register Now for Crash Course: Python For Cheminformatics-Driven Molecular Docking

• 03/27 Guide to Understanding PDB Data: Computed Structure Models

• 03/24 Developers: Switch to Sequence Coordinates Service by May 31, 2025

• 03/20 Meet RCSB PDB at the American Chemical Society Meeting

• 03/19 March 24 is World TB Day

• 03/15 PDB-101 Focus: Peak Performance

• 03/11 wwPDB News: Poster Prize Awarded at The Biophysical Society Meeting

• 03/10 wwPDB News: New version of PDB-IHM validation reports now include assessments of crosslinking mass spectrometry-based structure models

• 03/09 March 10-16: Brain Awareness Week

• 03/06 Register for the April 10 Virtual Office Hour on Sequence Annotations Viewer

• 03/05 IUCr2026 Awaits

• 03/04 Take the User Survey on Statistics and Win

• 03/04 Molecular Landscapes

• 03/03 Register for the May 8 Workshop on PDB Deposition

• 03/03 Register for March Training Events

• 03/02 March 4 is International HPV Awareness Day

• 02/25 Register for the April 7 Virtual Office Hour on Depositing IHM Data

• 02/25 Paper Published: From two epidemics to the global pandemic to mRNA vaccines and Paxlovid

• 02/21 Paper Published: Impact of the PDB on drug approvals

• 02/17 PDB-101 Focus: Peak Performance

• 02/17 Register Now for Webinar on API Access with Python

• 02/13 Meet RCSB PDB at The Biophysical Society Meeting

• 02/10 Register for the March 13 Virtual Office Hour on Supporting Extended PDB IDs

• 02/09 Molecular Valentines

• 02/05 Behind Molecule of the Month

• 02/02 Register Now for Webinar on Seeing Bird Flu in 3D

• 02/01 February 4 is World Cancer Day

• 01/28 Frontiers in Data Panel Webinar: Preparing Structural Science Data for 2085

• 01/23 Award-Winning Image

• 01/23 Developers: Collaborate with RCSB PDB at Rutgers

• 01/21 Watch the Webinar: Unlock Rapid Analyses Across the Whole PDB Using BinaryCIF

• 01/19 January is Cervical Cancer Awareness Month

• 01/17 Undergrads: Spend your summer with RCSB PDB

• 01/16 wwPDB News: PDB-Dev now PDB-IHM

• 01/16 Top Molecules of the Month in 2024

• 01/14 Winter Newsletter Published

• 01/12 Paper Published: Updated resources for exploring PDB structures and Computed Structure Models

• 01/09 Celebrate #NationalMilkDay

• 01/05 wwPDB News: Time-stamped Copies of PDB and EMDB Archives

• 01/05 Molecule of the Month: Celebrating 25 Years of Storytelling and Announcing New Beginnings