Download MendeleyWild-Type Human Pancreatic Alpha-Amylase at True Atomic Resolution (1.07 A)
Caner, S., Brayer, G.D.To be published.
4X9Y | pdb_00004x9y
Wild-Type Human Pancreatic Alpha-Amylase at True Atomic Resolution (1.07 A)
- PDB DOI: https://doi.org/10.2210/pdb4X9Y/pdb
- Classification: HYDROLASE
- Organism(s): Homo sapiens
- Expression System: Komagataella pastoris
- Mutation(s): No
- Deposited: 2014-12-11 Released: 2014-12-31
- Funding Organization(s): Canadian Institutes of Health Research (CIHR)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.07 Å
- R-Value Free: 0.132 (Depositor), 0.130 (DCC)
- R-Value Work: 0.113 (Depositor), 0.110 (DCC)
- R-Value Observed: 0.114 (Depositor)
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
This is version 2.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Pancreatic alpha-amylase | 496 | Homo sapiens | Mutation(s): 0 Gene Names: AMY2A EC: 3.2.1.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P04746 (Homo sapiens) Explore P04746 Go to UniProtKB: P04746 | |||||
PHAROS: P04746 GTEx: ENSG00000243480 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P04746 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| CA Query on CA | C [auth A] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
| CL Query on CL | B [auth A] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |  | ||
| Modified Residues 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Type | Formula | 2D Diagram | Parent |
| PCA Query on PCA | A | L-PEPTIDE LINKING | C5 H7 N O3 |  | GLN |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.07 Å
- R-Value Free: 0.132 (Depositor), 0.130 (DCC)
- R-Value Work: 0.113 (Depositor), 0.110 (DCC)
- R-Value Observed: 0.114 (Depositor)
Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 52.2 | α = 90 |
| b = 67.75 | β = 90 |
| c = 130.23 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| XSCALE | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2014-12-31 Deposition Author(s): Caner, S., Brayer, G.D.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Canadian Institutes of Health Research (CIHR) | Canada | -- |
Revision History (Full details and data files)
- Version 1.0: 2014-12-31
Type: Initial release - Version 1.1: 2015-02-04
Changes: Derived calculations - Version 1.2: 2017-08-23
Changes: Advisory, Data collection, Derived calculations, Refinement description, Source and taxonomy - Version 1.3: 2017-09-27
Changes: Author supporting evidence - Version 2.0: 2020-01-08
Changes: Author supporting evidence, Polymer sequence - Version 2.1: 2023-09-27
Changes: Data collection, Database references, Derived calculations, Refinement description - Version 2.2: 2024-10-23
Changes: Structure summary
