Download MendeleyTrypanosoma cruzi D-3-hydroxybutyrate dehydrogenase (HBDH) is NADP-dependent enzyme.
Hashimoto, H., Debler, E.W.To be published.
9C5O | pdb_00009c5o
Trypanosoma cruzi R42F mutant beta-3-HBDH structure
- PDB DOI: https://doi.org/10.2210/pdb9C5O/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Trypanosoma cruzi
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): Yes
- Deposited: 2024-06-06 Released: 2025-08-27
- Funding Organization(s): National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.69 Å
- R-Value Free: 0.180 (Depositor), 0.178 (DCC)
- R-Value Work: 0.160 (Depositor), 0.158 (DCC)
- R-Value Observed: 0.160 (Depositor)
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Hydroxybutyrate dehydrogenase | 270 | Trypanosoma cruzi | Mutation(s): 1 Gene Names: C4B63_13g310 EC: 1.1.1.100 |  | |
UniProt | |||||
Find proteins for A0A2V2VPF1 (Trypanosoma cruzi) Explore A0A2V2VPF1 Go to UniProtKB: A0A2V2VPF1 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | A0A2V2VPF1 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| EDO Query on EDO | E [auth B], F [auth B], G [auth B] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.69 Å
- R-Value Free: 0.180 (Depositor), 0.178 (DCC)
- R-Value Work: 0.160 (Depositor), 0.158 (DCC)
- R-Value Observed: 0.160 (Depositor)
Space Group: C 1 2 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 118.29 | α = 90 |
| b = 80.9 | β = 107.5 |
| c = 121.74 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| XSCALE | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-08-27 Deposition Author(s): Hashimoto, H., Debler, E.W.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | United States | R01AI165840 |
Revision History (Full details and data files)
- Version 1.0: 2025-08-27
Type: Initial release
