Download MendeleyEngineered nucleoside 2'-deoxyribonsyltransferase enzymes enable scalable synthesis of diverse nucleoside analogues
Tang, P., Harding, C.J., Czekster, C.M.To be published.
9EMW | pdb_00009emw
Nucleoside 2'deoxyribosyltransferase from Chroococcidiopsis thermalis PCC 7203 Y7F Mutant bound to ImmH-Forodesine
- PDB DOI: https://doi.org/10.2210/pdb9EMW/pdb
- Classification: TRANSFERASE
- Organism(s): Chroococcidiopsis thermalis PCC 7203
- Expression System: Escherichia coli B
- Mutation(s): Yes
- Deposited: 2024-03-11 Released: 2025-05-14
- Funding Organization(s): Other private
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.51 Å
- R-Value Free: 0.253 (Depositor), 0.270 (DCC)
- R-Value Work: 0.187 (Depositor), 0.204 (DCC)
- R-Value Observed: 0.190 (Depositor)
Starting Models: experimental
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Nucleoside 2-deoxyribosyltransferase | 154 | Chroococcidiopsis thermalis PCC 7203 | Mutation(s): 1 Gene Names: Chro_1188 |  | |
UniProt | |||||
Find proteins for K9TVX3 (Chroococcidiopsis thermalis (strain PCC 7203)) Explore K9TVX3 Go to UniProtKB: K9TVX3 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | K9TVX3 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| IMH (Subject of Investigation/LOI) Query on IMH | E [auth A], F [auth B], G [auth C], H [auth D] | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL C11 H14 N4 O4 IWKXDMQDITUYRK-KUBHLMPHSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.51 Å
- R-Value Free: 0.253 (Depositor), 0.270 (DCC)
- R-Value Work: 0.187 (Depositor), 0.204 (DCC)
- R-Value Observed: 0.190 (Depositor)
Space Group: P 63
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 135.76 | α = 90 |
| b = 135.76 | β = 90 |
| c = 87.55 | γ = 120 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| xia2 | data reduction |
| DIALS | data scaling |
| PHENIX | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-05-14 Deposition Author(s): Tang, P., Harding, C.J., Czekster, C.M.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Other private | United Kingdom | IBioIC 2020-2-1 |
Revision History (Full details and data files)
- Version 1.0: 2025-05-14
Type: Initial release
