Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00421
Krojer, T., Kozielski, F., Sele, C., Nyblom, M., Fisher, S.Z., Knecht, W.To be published.
Experimental Data Snapshot
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Non-structural protein 10 | 131 | Severe acute respiratory syndrome coronavirus 2 | Mutation(s): 0  | ![]() | |
UniProt | |||||
Find proteins for P0DTC1 (Severe acute respiratory syndrome coronavirus 2) Explore P0DTC1  Go to UniProtKB:  P0DTC1 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P0DTC1 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 2 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Guanine-N7 methyltransferase nsp14 | 290 | Severe acute respiratory syndrome coronavirus 2 | Mutation(s): 0  Gene Names: rep, 1a-1b EC: 2.1.1.56 (PDB Primary Data), 3.1.13 (PDB Primary Data) | ![]() | |
UniProt | |||||
Find proteins for P0DTD1 (Severe acute respiratory syndrome coronavirus 2) Explore P0DTD1  Go to UniProtKB:  P0DTD1 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P0DTD1 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 3 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
A1IGI (Subject of Investigation/LOI) Query on A1IGI | C [auth A] | N,N-dimethyl-3-oxidanyl-benzamide C9 H11 N O2 TULKODADVOEVTR-UHFFFAOYSA-N | |||
DMS Query on DMS | F [auth B] | DIMETHYL SULFOXIDE C2 H6 O S IAZDPXIOMUYVGZ-UHFFFAOYSA-N | |||
ZN Query on ZN | D [auth A], E [auth A], G [auth B], H [auth B] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
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a = 43.811 | α = 90 |
b = 100.392 | β = 114.53 |
c = 51.261 | γ = 90 |
Software Name | Purpose |
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autoPROC | data processing |
XDS | data reduction |
Aimless | data scaling |
TRUNCATE | data processing |
BUSTER | refinement |
Funding Organization | Location | Grant Number |
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Not funded | -- |