Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8
Rai, A., Janning, P., Vetter, I.R., Goody, R.S.(2024) Elife 
Experimental Data Snapshot
Starting Model: experimental
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(2024) Elife 
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
[F-actin]-monooxygenase MICAL1 | 153 | Homo sapiens | Mutation(s): 2  Gene Names: MICAL1, MICAL, NICAL EC: 1.14.13.225 (PDB Primary Data), 1.6.3.1 (PDB Primary Data) | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q8TDZ2 (Homo sapiens) Explore Q8TDZ2  Go to UniProtKB:  Q8TDZ2 | |||||
PHAROS:  Q8TDZ2 GTEx:  ENSG00000135596  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q8TDZ2 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 2 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Ras-related protein Rab-10 | 177 | Homo sapiens | Mutation(s): 0  Gene Names: RAB10 EC: 3.6.5.2 | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P61026 (Homo sapiens) Explore P61026  Go to UniProtKB:  P61026 | |||||
PHAROS:  P61026 GTEx:  ENSG00000084733  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P61026 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 2 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
GNP (Subject of Investigation/LOI) Query on GNP | C [auth B] | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER C10 H17 N6 O13 P3 UQABYHGXWYXDTK-UUOKFMHZSA-N | |||
MG (Subject of Investigation/LOI) Query on MG | D [auth B] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
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a = 53.39 | α = 90 |
b = 48.56 | β = 97.98 |
c = 78.77 | γ = 90 |
Software Name | Purpose |
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PHENIX | refinement |
XDS | data reduction |
XSCALE | data scaling |
PHASER | phasing |
Funding Organization | Location | Grant Number |
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Max Planck Society | Germany | -- |
German Research Foundation (DFG) | Germany | grant GO 284/10-1 |