Download MendeleyBiochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8
Rai, A., Janning, P., Vetter, I.R., Goody, R.S.(2024) Elife
9G0D | pdb_00009g0d
Structure of human Mical1 bMERB_V978A domain:Rab10 complex.
- PDB DOI: https://doi.org/10.2210/pdb9G0D/pdb
- Classification: ENDOCYTOSIS
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2024-07-08 Released: 2025-07-02
- Funding Organization(s): Max Planck Society, German Research Foundation (DFG)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.05 Å
- R-Value Free: 0.249 (Depositor), 0.251 (DCC)
- R-Value Work: 0.201 (Depositor), 0.202 (DCC)
- R-Value Observed: 0.203 (Depositor)
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| [F-actin]-monooxygenase MICAL1 | A [auth B] | 153 | Homo sapiens | Mutation(s): 1 Gene Names: MICAL1, MICAL, NICAL EC: 1.14.13.225 (PDB Primary Data), 1.6.3.1 (PDB Primary Data) |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q8TDZ2 (Homo sapiens) Explore Q8TDZ2 Go to UniProtKB: Q8TDZ2 | |||||
PHAROS: Q8TDZ2 GTEx: ENSG00000135596 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q8TDZ2 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Ras-related protein Rab-10 | B [auth C] | 177 | Homo sapiens | Mutation(s): 0 Gene Names: RAB10 EC: 3.6.5.2 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P61026 (Homo sapiens) Explore P61026 Go to UniProtKB: P61026 | |||||
PHAROS: P61026 GTEx: ENSG00000084733 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P61026 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GNP (Subject of Investigation/LOI) Query on GNP | C | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER C10 H17 N6 O13 P3 UQABYHGXWYXDTK-UUOKFMHZSA-N |  | ||
| MG (Subject of Investigation/LOI) Query on MG | D [auth C] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.05 Å
- R-Value Free: 0.249 (Depositor), 0.251 (DCC)
- R-Value Work: 0.201 (Depositor), 0.202 (DCC)
- R-Value Observed: 0.203 (Depositor)
Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 53.77 | α = 90 |
| b = 49.65 | β = 98.54 |
| c = 79.33 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| XSCALE | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-07-02 Deposition Author(s): Rai, A., Goody, R.S.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Max Planck Society | Germany | -- |
| German Research Foundation (DFG) | Germany | grant GO 284/10-1 |
Revision History (Full details and data files)
- Version 1.0: 2025-07-02
Type: Initial release
