9JAI | pdb_00009jai

GMPK in complex with GMP and ADP

  • Classification: TRANSFERASE
  • Organism(s): Homo sapiens
  • Expression System: Escherichia coli
  • Mutation(s): No 

  • Deposited: 2024-08-24 Released: 2025-09-03 
  • Deposition Author(s): Wang, L., Ruan, K.
  • Funding Organization(s): Ministry of Science and Technology (MoST, China), National Natural Science Foundation of China (NSFC), Other private

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.30 Å
  • R-Value Free: 
    0.249 (Depositor), 0.250 (DCC) 
  • R-Value Work: 
    0.195 (Depositor), 0.196 (DCC) 
  • R-Value Observed: 
    0.198 (Depositor) 

Starting Model: experimental
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wwPDB Validation   3D Report Full Report


Ligand Structure Quality Assessment 


This is version 1.0 of the entry. See complete history. 


Literature

Comprehensive profiling of the catalytic conformations of human Guanylate kinase

Wang, L., Ruan, K.

To be published.

Macromolecules
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(by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Guanylate kinase
A, B
198Homo sapiensMutation(s): 0 
Gene Names: GUK1, GMK, GMPK
EC: 2.7.4.8
UniProt & NIH Common Fund Data Resources
Find proteins for Q16774 (Homo sapiens)
Explore Q16774 
Go to UniProtKB:  Q16774
PHAROS:  Q16774
GTEx:  ENSG00000143774 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ16774
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.30 Å
  • R-Value Free:  0.249 (Depositor), 0.250 (DCC) 
  • R-Value Work:  0.195 (Depositor), 0.196 (DCC) 
  • R-Value Observed: 0.198 (Depositor) 
Space Group: P 1 21 1
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 43.77α = 90
b = 62.92β = 107.31
c = 66.16γ = 90
Software Package:
Software NamePurpose
PHENIXrefinement
Aimlessdata scaling
XDSdata reduction
MOLREPphasing

Structure Validation

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Ligand Structure Quality Assessment 


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Entry History & Funding Information

Deposition Data

Funding OrganizationLocationGrant Number
Ministry of Science and Technology (MoST, China)China2019YFA0508400
National Natural Science Foundation of China (NSFC)China22377119
Other privateChinaYD9100002028

Revision History  (Full details and data files)

  • Version 1.0: 2025-09-03
    Type: Initial release