Download MendeleyStructural Basis for the Modulation of Ryanodine Receptor by Dantrolene and Azumolene
Hadiatullah, H., Lin, L., Yuchi, Z.To be published.
9L91 | pdb_00009l91
The crystal structure of human RyR3 Repeat12 domain in complex with Azumolene and AMP-PCP
- PDB DOI: https://doi.org/10.2210/pdb9L91/pdb
- Classification: MEMBRANE PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli 'BL21-Gold(DE3)pLysS AG
- Mutation(s): No
- Deposited: 2024-12-29 Released: 2025-10-22
- Funding Organization(s): Not funded
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 3.00 Å
- R-Value Free: 0.317 (Depositor), 0.310 (DCC)
- R-Value Work: 0.268 (Depositor), 0.261 (DCC)
- R-Value Observed: 0.281 (Depositor)
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Ryanodine receptor 3 | A [auth B], B [auth A], C, D | 218 | Homo sapiens | Mutation(s): 0 Gene Names: RYR3, HBRR |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q15413 (Homo sapiens) Explore Q15413 Go to UniProtKB: Q15413 | |||||
PHAROS: Q15413 GTEx: ENSG00000198838 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q15413 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ACP (Subject of Investigation/LOI) Query on ACP | E [auth B], G [auth A] | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER C11 H18 N5 O12 P3 UFZTZBNSLXELAL-IOSLPCCCSA-N |  | ||
| A1L7B (Subject of Investigation/LOI) Query on A1L7B | F [auth B], H [auth A] | Azumolene C13 H9 Br N4 O3 SEGCNGONCZQFDW-OMCISZLKSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 3.00 Å
- R-Value Free: 0.317 (Depositor), 0.310 (DCC)
- R-Value Work: 0.268 (Depositor), 0.261 (DCC)
- R-Value Observed: 0.281 (Depositor)
Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 261.666 | α = 90 |
| b = 59.96 | β = 90 |
| c = 60.759 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| Aimless | data scaling |
| HKL-2000 | data reduction |
| PHENIX | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-10-22 Deposition Author(s): Hadiatullah, H., Lin, L., Yuchi, Z.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Not funded | -- |
Revision History (Full details and data files)
- Version 1.0: 2025-10-22
Type: Initial release
