9LVX | pdb_00009lvx

di-hexamer form of insulin detemir at ambient temperature

PDB DOI: https://doi.org/10.2210/pdb9LVX/pdb

Classification: HORMONE
Organism(s): Homo sapiens
Expression System: Escherichia coli
Mutation(s): No

Deposited: 2025-02-13 Released: 2025-02-26
Deposition Author(s): Ayan, E., Bahar, I.
Funding Organization(s): Other government

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 2.70 Å
R-Value Free:
0.322 (Depositor), 0.326 (DCC)
R-Value Work:
0.273 (Depositor), 0.273 (DCC)
R-Value Observed:
0.278 (Depositor)

Starting Model: experimental
View more details

wwPDB Validation 3D Report Full Report

Ligand Structure Quality Assessment

This is version 1.0 of the entry. See complete history.

Literature

di-hexamer form of insulin detemir at ambient temperature

Ayan, E., Bahar, I.

To be published.

Macromolecule Content

Total Structure Weight: 24.56 kDa
Atom Count: 1,856
Modelled Residue Count: 200
Deposited Residue Count: 200
Unique protein chains: 2

Macromolecules

Find similar proteins by: Sequence | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Insulin A chain	A, C, E, G	21	Homo sapiens	Mutation(s): 0 Gene Names: INS
UniProt & NIH Common Fund Data Resources
Find proteins for P01308 (Homo sapiens) Explore P01308 Go to UniProtKB: P01308
PHAROS: P01308 GTEx: ENSG00000254647
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P01308
Sequence Annotations Expand
Reference Sequence

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 2
Molecule	Chains	Sequence Length	Organism	Details	Image
Insulin B chain	B, D, F, H	29	Homo sapiens	Mutation(s): 0 Gene Names: INS
UniProt & NIH Common Fund Data Resources
Find proteins for P01308 (Homo sapiens) Explore P01308 Go to UniProtKB: P01308
PHAROS: P01308 GTEx: ENSG00000254647
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P01308
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 4 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
MYR (Subject of Investigation/LOI) Query on MYR Download Ideal Coordinates CCD File SDF format, chain L [auth B] SDF format, chain P [auth D] SDF format, chain T [auth F] SDF format, chain X [auth H] MOL2 format, chain L [auth B] MOL2 format, chain P [auth D] MOL2 format, chain T [auth F] MOL2 format, chain X [auth H] mmCIF format, chain L [auth B] mmCIF format, chain P [auth D] mmCIF format, chain T [auth F] mmCIF format, chain X [auth H]	L [auth B], P [auth D], T [auth F], X [auth H]	MYRISTIC ACID C₁₄ H₂₈ O₂ TUNFSRHWOTWDNC-UHFFFAOYSA-N		Interactions Focus chain L [auth B] Focus chain P [auth D] Focus chain T [auth F] Focus chain X [auth H] Interactions & Density Focus chain L [auth B] Focus chain P [auth D] Focus chain T [auth F] Focus chain X [auth H]
IPH (Subject of Investigation/LOI) Query on IPH Download Ideal Coordinates CCD File SDF format, chain I [auth B] SDF format, chain M [auth D] SDF format, chain Q [auth F] SDF format, chain U [auth H] MOL2 format, chain I [auth B] MOL2 format, chain M [auth D] MOL2 format, chain Q [auth F] MOL2 format, chain U [auth H] mmCIF format, chain I [auth B] mmCIF format, chain M [auth D] mmCIF format, chain Q [auth F] mmCIF format, chain U [auth H]	I [auth B], M [auth D], Q [auth F], U [auth H]	PHENOL C₆ H₆ O ISWSIDIOOBJBQZ-UHFFFAOYSA-N		Interactions Focus chain I [auth B] Focus chain M [auth D] Focus chain Q [auth F] Focus chain U [auth H] Interactions & Density Focus chain I [auth B] Focus chain M [auth D] Focus chain Q [auth F] Focus chain U [auth H]
ZN (Subject of Investigation/LOI) Query on ZN Download Ideal Coordinates CCD File SDF format, chain J [auth B] SDF format, chain N [auth D] SDF format, chain R [auth F] SDF format, chain V [auth H] MOL2 format, chain J [auth B] MOL2 format, chain N [auth D] MOL2 format, chain R [auth F] MOL2 format, chain V [auth H] mmCIF format, chain J [auth B] mmCIF format, chain N [auth D] mmCIF format, chain R [auth F] mmCIF format, chain V [auth H]	J [auth B], N [auth D], R [auth F], V [auth H]	ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N		Interactions Focus chain J [auth B] Focus chain N [auth D] Focus chain R [auth F] Focus chain V [auth H] Interactions & Density Focus chain J [auth B] Focus chain N [auth D] Focus chain R [auth F] Focus chain V [auth H]
CL (Subject of Investigation/LOI) Query on CL Download Ideal Coordinates CCD File SDF format, chain K [auth B] SDF format, chain O [auth D] SDF format, chain W [auth H] SDF format, chain S [auth F] MOL2 format, chain K [auth B] MOL2 format, chain O [auth D] MOL2 format, chain W [auth H] MOL2 format, chain S [auth F] mmCIF format, chain K [auth B] mmCIF format, chain O [auth D] mmCIF format, chain W [auth H] mmCIF format, chain S [auth F]	K [auth B], O [auth D], S [auth F], W [auth H]	CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M		Interactions Focus chain K [auth B] Focus chain O [auth D] Focus chain S [auth F] Focus chain W [auth H] Interactions & Density Focus chain K [auth B] Focus chain O [auth D] Focus chain S [auth F] Focus chain W [auth H]