Download MendeleyStructure-function studies of Vibrio cholerae quorum-sensing receptor CqsR signal recognition
Guarnaccia, A.M., Steenhaut, A.D., Olenic, S.D., Na, J., Perez, L.J., Ng, W.L., Neiditch, M.B.To be published.
9NIT | pdb_00009nit
Crystal structure of Vibrio cholerae CqsR bound to L-alaninol
- PDB DOI: https://doi.org/10.2210/pdb9NIT/pdb
- Classification: SIGNALING PROTEIN
- Organism(s): Vibrio cholerae C6706
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2025-02-26 Released: 2025-07-02
- Funding Organization(s): National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID), National Institutes of Health/National Center for Advancing Translational Sciences (NIH/NCATS)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.72 Å
- R-Value Free: 0.220 (Depositor), 0.220 (DCC)
- R-Value Work: 0.180 (Depositor), 0.180 (DCC)
- R-Value Observed: 0.184 (Depositor)
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| histidine kinase | 217 | Vibrio cholerae C6706 | Mutation(s): 0 Gene Names: VC_1831 EC: 2.7.13.3 |  | |
UniProt | |||||
Find proteins for Q9KR16 (Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)) Explore Q9KR16 Go to UniProtKB: Q9KR16 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9KR16 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 2A1 (Subject of Investigation/LOI) Query on 2A1 | B [auth A] | (2S)-2-aminopropan-1-ol C3 H9 N O BKMMTJMQCTUHRP-VKHMYHEASA-N |  | ||
| CL Query on CL | C [auth A] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.72 Å
- R-Value Free: 0.220 (Depositor), 0.220 (DCC)
- R-Value Work: 0.180 (Depositor), 0.180 (DCC)
- R-Value Observed: 0.184 (Depositor)
Space Group: I 41 2 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 121.024 | α = 90 |
| b = 121.024 | β = 90 |
| c = 70.545 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| PHASER | phasing |
| CrysalisPro | data reduction |
| CrysalisPro | data scaling |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-07-02 Deposition Author(s): Guarnaccia, A.M., Neiditch, M.B.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | United States | AI121337 |
| National Institutes of Health/National Center for Advancing Translational Sciences (NIH/NCATS) | United States | TL1TR003019 |
Revision History (Full details and data files)
- Version 1.0: 2025-07-02
Type: Initial release
