Download MendeleyGating and noelin clustering of native Ca2+-permeable AMPA receptors
Fang, C., Spangler, C.J., Park, J., Sheldon, N., Trussell, L.O., Gouaux, E.(2025) Nature
9NRA | pdb_00009nra
The structure of GluA1/A4 LBD-TMD with 4 auxiliary subunits
- PDB DOI: https://doi.org/10.2210/pdb9NRA/pdb
- EM Map EMD-49727: EMDB EMDataResource
- Classification: MEMBRANE PROTEIN
- Organism(s): Rattus norvegicus
- Mutation(s): No
- Deposited: 2025-03-14 Released: 2025-07-02
- Funding Organization(s): Howard Hughes Medical Institute (HHMI)
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 4.18 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Glutamate receptor 1 | 427 | Rattus norvegicus | Mutation(s): 0 |  | |
UniProt | |||||
Find proteins for P19490 (Rattus norvegicus) Explore P19490 Go to UniProtKB: P19490 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P19490 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Isoform 2 of Glutamate receptor 4 | 424 | Rattus norvegicus | Mutation(s): 0 |  | |
UniProt | |||||
Find proteins for P19493 (Rattus norvegicus) Go to UniProtKB: P19493 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P19493-2 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Auxiliary protein at A'/C' | 117 | Rattus norvegicus | Mutation(s): 0 |  | |
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 4 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Voltage-dependent calcium channel gamma-2 subunit | 204 | Rattus norvegicus | Mutation(s): 0 |  | |
UniProt | |||||
Find proteins for Q71RJ2 (Rattus norvegicus) Explore Q71RJ2 Go to UniProtKB: Q71RJ2 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q71RJ2 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ZK1 Query on ZK1 | I [auth A], J [auth B], K [auth C], L [auth D] | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid C14 H15 F3 N3 O6 P WZMQMKNCWDCCMT-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 4.18 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
| Task | Software Package | Version |
|---|---|---|
| MODEL REFINEMENT | PHENIX | 1.20.1_4487: |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-07-02 Deposition Author(s): Fang, C.F., Gouaux, E.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Howard Hughes Medical Institute (HHMI) | United States | -- |
Revision History (Full details and data files)
- Version 1.0: 2025-07-02
Type: Initial release
