1C44 | pdb_00001c44

STEROL CARRIER PROTEIN 2 (SCP2) FROM RABBIT

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1c44a_	Alpha and beta proteins (a+b)	SCP-like	SCP-like	Sterol carrier protein, SCP	Sterol carrier protein 2 (SCP2)	rabbit (Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Sterol carrier protein (SCP)-related	8023634	4000360	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SCP2-like	8036014	3000148	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SCP2	e1c44A1	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02036	SCP-2 sterol transfer family (SCP2)	SCP-2 sterol transfer family	This domain is involved in binding sterols. It is found in the SCP2 protein Swiss:P22307, as well as the C terminus of Swiss:P51659 the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein Swiss:Q17372 contains an SPFH domain Pfam:P ...	This domain is involved in binding sterols. It is found in the SCP2 protein Swiss:P22307, as well as the C terminus of Swiss:P51659 the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein Swiss:Q17372 contains an SPFH domain Pfam:PF01145 [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTEIN (STEROL CARRIER PROTEIN 2)	acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity acetyl-CoA C-acyltransferase activity C-acyltransferase activity catalytic activity sterol transfer activity lipid transporter activity lipid transfer activity transporter activity cholesterol transfer activity phospholipid transfer activity phosphatidylcholine transporter activity phosphatidylcholine transfer activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity acetyl-CoA C-acyltransferase activity C-acyltransferase activity catalytic activity sterol transfer activity lipid transporter activity lipid transfer activity transporter activity cholesterol transfer activity phospholipid transfer activity phosphatidylcholine transporter activity phosphatidylcholine transfer activity phospholipid transporter activity binding lipid binding propionyl-CoA C2-trimethyltridecanoyltransferase activity propanoyl-CoA C-acyltransferase activity myristoyltransferase activity acetyl-CoA C-myristoyltransferase activity	cellular localization transport intracellular lipid transport intracellular cholesterol transport lipid localization lipid transport intracellular transport organic hydroxy compound transport intracellular sterol transport establishment of localization localization macromolecule localization establishment of localization in cell cellular process cellular localization transport intracellular lipid transport intracellular cholesterol transport lipid localization lipid transport intracellular transport organic hydroxy compound transport intracellular sterol transport establishment of localization localization macromolecule localization establishment of localization in cell cellular process cholesterol transport sterol transport oxoacid metabolic process steroid metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process bile acid metabolic process metabolic process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process fatty acid metabolic process lipid catabolic process catabolic process lipid modification organic acid catabolic process fatty acid catabolic process monocarboxylic acid catabolic process fatty acid oxidation carboxylic acid catabolic process fatty acid beta-oxidation lipid oxidation small molecule catabolic process regulation of cellular process regulation of lipid metabolic process lipid biosynthetic process regulation of primary metabolic process phospholipid metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process regulation of biosynthetic process regulation of biological process biological regulation regulation of phospholipid metabolic process phospholipid biosynthetic process regulation of phospholipid biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process regulation of phosphorus metabolic process regulation of lipid biosynthetic process regulation of metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle peroxisome microbody peroxisomal matrix membrane-enclosed lumen intracellular organelle lumen organelle lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle peroxisome microbody peroxisomal matrix membrane-enclosed lumen intracellular organelle lumen organelle lumen microbody lumen endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003033	SCP2 sterol-binding domain	Domain
A	IPR016039	Thiolase-like	Homologous Superfamily
A	IPR055140	Thiolase, C-terminal domain 2	Domain
A	IPR020616	Thiolase, N-terminal	Domain
A	IPR020613	Thiolase, conserved site	Conserved Site
A	IPR036527	SCP2 sterol-binding domain superfamily	Homologous Superfamily
A	IPR020615	Thiolase, acyl-enzyme intermediate active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.