Annotations: 1G63

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1g63a_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)
B	d1g63b_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)
K	d1g63k_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)
L	d1g63l_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)
J	d1g63j_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)
I	d1g63i_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)
H	d1g63h_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)
G	d1g63g_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)
F	d1g63f_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)
E	d1g63e_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)
D	d1g63d_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)
C	d1g63c_	Alpha and beta proteins (a/b)	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Epidermin modifying enzyme (peptidyl-cysteine decarboxylase) EpiD	(Staphylococcus epidermidis ) [TaxId: 1282 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	8032599	3001775	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Flavoprotein	e1g63A1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)
B	Flavoprotein	e1g63B1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)
K	Flavoprotein	e1g63K1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)
L	Flavoprotein	e1g63L1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)
J	Flavoprotein	e1g63J1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)
I	Flavoprotein	e1g63I1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)
H	Flavoprotein	e1g63H1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)
G	Flavoprotein	e1g63G1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)
F	Flavoprotein	e1g63F1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)
E	Flavoprotein	e1g63E1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)
D	Flavoprotein	e1g63D1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)
C	Flavoprotein	e1g63C1	A: a/b three-layered sandwiches	X: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	H: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (From Topology)	T: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	F: Flavoprotein	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)
B	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)
K	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)
L	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)
J	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)
I	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)
H	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)
G	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)
F	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)
E	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)
D	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)
C	3.40.50.1950	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavin prenyltransferase-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF02441	Flavoprotein (Flavoprotein)	Flavoprotein	This domain is found in diverse flavoprotein enzymes, including covering the whole length of the sequence of epidermin biosynthesis protein from Staphylococcus epidermidis (EpiD, Swiss:P30197), which has been shown to bind FMN [1]. This enzyme cataly ...	This domain is found in diverse flavoprotein enzymes, including covering the whole length of the sequence of epidermin biosynthesis protein from Staphylococcus epidermidis (EpiD, Swiss:P30197), which has been shown to bind FMN [1]. This enzyme catalyses the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance [2]. dipicolinate synthase catalyses the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase Swiss:P33751 (EC:4.1.1.-) [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	EPIDERMIN MODIFYING ENZYME EPID	FMN binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding phosphopantothenoylcysteine decarboxylase activity carboxy-lyase activity lyase activity catalytic activity FMN binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding phosphopantothenoylcysteine decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity	nucleoside phosphate metabolic process coenzyme A biosynthetic process amide biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process nucleobase-containing compound metabolic process sulfur compound biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process nucleoside phosphate biosynthetic process phosphate-containing compound metabolic process nucleoside phosphate metabolic process coenzyme A biosynthetic process amide biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process nucleobase-containing compound metabolic process sulfur compound biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process nucleoside phosphate biosynthetic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process sulfur compound metabolic process amide metabolic process phosphorus metabolic process coenzyme A metabolic process	protein-containing complex cellular anatomical structure intracellular anatomical structure catalytic complex cytoplasm phosphopantothenoylcysteine decarboxylase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR036551	Flavin prenyltransferase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR003382	Flavoprotein	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.