1KZ7 | pdb_00001kz7

Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1kz7a1 All alpha proteins DBL homology domain (DH-domain) DBL homology domain (DH-domain) DBL homology domain (DH-domain) Dbl's big sister, Dbs house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
Ad1kz7a2 All beta proteins PH domain-like barrel PH domain-like Pleckstrin-homology domain (PH domain) Dbl's big sister, Dbs house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
Cd1kz7c1 All alpha proteins DBL homology domain (DH-domain) DBL homology domain (DH-domain) DBL homology domain (DH-domain) Dbl's big sister, Dbs house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
Cd1kz7c2 All beta proteins PH domain-like barrel PH domain-like Pleckstrin-homology domain (PH domain) Dbl's big sister, Dbs house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
Bd1kz7b_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins CDC42 human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd1kz7d_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins CDC42 human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyDBL homology domain (DH-domain) 8028477 4001108 SCOP2 (2022-06-29)
ASCOP2 FamilyPleckstrin-homology domain (PH domain) 8028479 4002395 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyDBL homology domain (DH-domain) 8040856 3000793 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyPH domain-like 8040858 3000134 SCOP2 (2022-06-29)
CSCOP2B SuperfamilyPH domain-like 8040858 3000134 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyDBL homology domain (DH-domain) 8040856 3000793 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyRas-like P-loop GTPases 8057416 3002022 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyRas-like P-loop GTPases 8057416 3002022 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APH_10e1kz7A1 A: beta barrelsX: PH domain-likeH: PH domain-like (From Topology)T: PH domain-likeF: PH_10ECOD (1.6)
ARhoGEFe1kz7A2 A: alpha bundlesX: DH domain-likeH: DBL homology domain (DH-domain) (From Topology)T: DBL homology domain (DH-domain)F: RhoGEFECOD (1.6)
CPH_10e1kz7C1 A: beta barrelsX: PH domain-likeH: PH domain-like (From Topology)T: PH domain-likeF: PH_10ECOD (1.6)
CRhoGEFe1kz7C2 A: alpha bundlesX: DH domain-likeH: DBL homology domain (DH-domain) (From Topology)T: DBL homology domain (DH-domain)F: RhoGEFECOD (1.6)
BRase1kz7B1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
DRase1kz7D1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.20.900.10 Mainly Alpha Up-down Bundle Dbl Homology Domain Chain ACATH (4.3.0)
A2.30.29.30 Mainly Beta Roll PH-domain like Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)CATH (4.3.0)
C1.20.900.10 Mainly Alpha Up-down Bundle Dbl Homology Domain Chain ACATH (4.3.0)
C2.30.29.30 Mainly Beta Roll PH-domain like Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)CATH (4.3.0)
B3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
D3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF22697SOS1/NGEF-like PH domain (SOS1_NGEF_PH)SOS1/NGEF-like PH domainThis is a PH domain found in a diverse group of animal proteins such as Ephexin-1, SOS1 from human and related RhoGEFs [1-5]. Domain
A, C
PF00621RhoGEF domain (RhoGEF)RhoGEF domainGuanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains. Domain
B, D
PF00071Ras family (Ras)Ras familyIncludes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motili ...Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS
B, D
CDC42 HOMOLOG

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C
IPR001251CRAL-TRIO lipid binding domainDomain
A, C
IPR001849Pleckstrin homology domainDomain
A, C
IPR036865CRAL-TRIO lipid binding domain superfamilyHomologous Superfamily
A, C
IPR056466Guanine nucleotide exchange factor DBS-like, spectrin-likeDomain
A, C
IPR000219Dbl homology domainDomain
A, C
IPR036028SH3-like domain superfamilyHomologous Superfamily
A, C
IPR035532DBS, SH3 domainDomain
A, C
IPR011993PH-like domain superfamilyHomologous Superfamily
A, C
IPR001331Guanine-nucleotide dissociation stimulator, CDC24, conserved siteConserved Site
A, C
IPR051336Rho GTPase-activating Guanine Nucleotide Exchange FactorsFamily
A, C
IPR035534DBS, PH domainDomain
A, C
IPR001452SH3 domainDomain
A, C
IPR035899Dbl homology (DH) domain superfamilyHomologous Superfamily
A, C
IPR018159Spectrin/alpha-actininRepeat
A, C
IPR055251SOS1/NGEF-like, PH domainDomain
A, C
IPR002017Spectrin repeatRepeat
B, D
IPR001806Small GTPaseFamily
B, D
IPR003578Small GTPase RhoFamily
B, D
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
B, D
IPR037874Cdc42Family
B, D
IPR005225Small GTP-binding domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
B, D
Pharos:  P60953