1LNL | pdb_00001lnl

Structure of deoxygenated hemocyanin from Rapana thomasiana

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1lnlc1	All alpha proteins	Di-copper centre-containing domain	Di-copper centre-containing domain	Hemocyanin middle domain	Mollusc hemocyanin	(Rapana venosa ) [TaxId: 55521 ],	SCOPe (2.08)
C	d1lnlc2	All beta proteins	C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	(Rapana venosa ) [TaxId: 55521 ],	SCOPe (2.08)
B	d1lnlb1	All alpha proteins	Di-copper centre-containing domain	Di-copper centre-containing domain	Hemocyanin middle domain	Mollusc hemocyanin	(Rapana venosa ) [TaxId: 55521 ],	SCOPe (2.08)
B	d1lnlb2	All beta proteins	C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	(Rapana venosa ) [TaxId: 55521 ],	SCOPe (2.08)
A	d1lnla1	All alpha proteins	Di-copper centre-containing domain	Di-copper centre-containing domain	Hemocyanin middle domain	Mollusc hemocyanin	(Rapana venosa ) [TaxId: 55521 ],	SCOPe (2.08)
A	d1lnla2	All beta proteins	C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	(Rapana venosa ) [TaxId: 55521 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Di-copper centre-containing domain	8032525	3000773	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	C-terminal domain of mollusc hemocyanin	8032527	3000431	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Di-copper centre-containing domain	8032525	3000773	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	C-terminal domain of mollusc hemocyanin	8032527	3000431	SCOP2B (2022-06-29)
A	SCOP2 Family	Hemocyanin middle domain	8020145	4001104	SCOP2 (2022-06-29)
A	SCOP2 Family	c-terminal domain of mollusc hemocyanin	8020147	4001822	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Di-copper centre-containing domain	8032525	3000773	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	C-terminal domain of mollusc hemocyanin	8032527	3000431	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Haemocyan_bet_s	e1lnlC1	A: beta sandwiches	X: jelly-roll	H: C-terminal domain of mullusc hemocyanin (From Topology)	T: C-terminal domain of mullusc hemocyanin	F: Haemocyan_bet_s	ECOD (1.6)
C	Tyrosinase	e1lnlC2	A: alpha arrays	X: Di-copper centre-containing domain (From Topology)	H: Di-copper centre-containing domain (From Topology)	T: Di-copper centre-containing domain	F: Tyrosinase	ECOD (1.6)
B	Haemocyan_bet_s	e1lnlB1	A: beta sandwiches	X: jelly-roll	H: C-terminal domain of mullusc hemocyanin (From Topology)	T: C-terminal domain of mullusc hemocyanin	F: Haemocyan_bet_s	ECOD (1.6)
B	Tyrosinase	e1lnlB2	A: alpha arrays	X: Di-copper centre-containing domain (From Topology)	H: Di-copper centre-containing domain (From Topology)	T: Di-copper centre-containing domain	F: Tyrosinase	ECOD (1.6)
A	Haemocyan_bet_s	e1lnlA1	A: beta sandwiches	X: jelly-roll	H: C-terminal domain of mullusc hemocyanin (From Topology)	T: C-terminal domain of mullusc hemocyanin	F: Haemocyan_bet_s	ECOD (1.6)
A	Tyrosinase	e1lnlA2	A: alpha arrays	X: Di-copper centre-containing domain (From Topology)	H: Di-copper centre-containing domain (From Topology)	T: Di-copper centre-containing domain	F: Tyrosinase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	1.10.1280.10	Mainly Alpha	Orthogonal Bundle	di-copper center containing domain from catechol oxidase	Di-copper center containing domain from catechol oxidase	CATH (4.3.0)
C	2.60.310.10	Mainly Beta	Sandwich	Hemocyanin	Chain: A, domain 2	CATH (4.3.0)
B	1.10.1280.10	Mainly Alpha	Orthogonal Bundle	di-copper center containing domain from catechol oxidase	Di-copper center containing domain from catechol oxidase	CATH (4.3.0)
B	2.60.310.10	Mainly Beta	Sandwich	Hemocyanin	Chain: A, domain 2	CATH (4.3.0)
A	1.10.1280.10	Mainly Alpha	Orthogonal Bundle	di-copper center containing domain from catechol oxidase	Di-copper center containing domain from catechol oxidase	CATH (4.3.0)
A	2.60.310.10	Mainly Beta	Sandwich	Hemocyanin	Chain: A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00264	Common central domain of tyrosinase (Tyrosinase)	Common central domain of tyrosinase	This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to Pfam:PF00372.	Domain
A, B, C	PF14830	Haemocyanin beta-sandwich (Haemocyan_bet_s)	Haemocyanin beta-sandwich	This antiparallel beta sandwich domain occurs in mollusc haemocyanins. Each mollusc haemocyanin contains several globular oxygen binding functional units. Each unit consists of an alpha-helical copper binding domain (Pfam:PF00264) and an antiparallel ...	This antiparallel beta sandwich domain occurs in mollusc haemocyanins. Each mollusc haemocyanin contains several globular oxygen binding functional units. Each unit consists of an alpha-helical copper binding domain (Pfam:PF00264) and an antiparallel beta sandwich domain [1-2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	hemocyanin	oxidoreductase activity catalytic activity oxygen carrier activity molecular carrier activity cation binding ion binding binding metal ion binding small molecule binding	-	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR008922	Di-copper centre-containing domain superfamily	Homologous Superfamily
A, B, C	IPR028999	Haemocyanin, beta-sandwich domain	Domain
A, B, C	IPR036848	Haemocyanin C-terminal domain superfamily	Homologous Superfamily
A, B, C	IPR050316	Tyrosinase and Hemocyanin	Family
A, B, C	IPR002227	Tyrosinase copper-binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.