Annotations: 1RGP

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1rgpa_	All alpha proteins	GTPase activation domain, GAP	GTPase activation domain, GAP	BCR-homology GTPase activation domain (BH-domain)	p50 RhoGAP domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GTPase activation domain, GAP	8038518	3001163	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RhoGAP	e1rgpA1	A: alpha bundles	X: GTPase activation domain, GAP (From Topology)	H: GTPase activation domain, GAP (From Topology)	T: GTPase activation domain, GAP	F: RhoGAP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.555.10	Mainly Alpha	Orthogonal Bundle	Phosphatidylinositol 3-kinase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00620	RhoGAP domain (RhoGAP)	RhoGAP domain	GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	RHOGAP	SH3 domain binding protein binding binding protein domain specific binding small GTPase binding enzyme binding GTPase binding cell adhesion molecule binding cadherin binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity SH3 domain binding protein binding binding protein domain specific binding small GTPase binding enzyme binding GTPase binding cell adhesion molecule binding cadherin binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity	localization cellular localization transport establishment of localization in cell cellular process intracellular transport establishment of localization vesicle-mediated transport endosomal transport regulation of localization regulation of cellular process negative regulation of biological process negative regulation of transport endocytic recycling localization cellular localization transport establishment of localization in cell cellular process intracellular transport establishment of localization vesicle-mediated transport endosomal transport regulation of localization regulation of cellular process negative regulation of biological process negative regulation of transport endocytic recycling negative regulation of cellular process regulation of endocytic recycling regulation of intracellular transport negative regulation of intracellular transport regulation of biological process regulation of transport biological regulation localization within membrane regulation of vesicle-mediated transport negative regulation of endocytic recycling vesicle-mediated transport to the plasma membrane regulation of cellular localization cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction Rho protein signal transduction establishment of protein localization nitrogen compound transport iron ion transport metal ion transport protein transport macromolecule localization transferrin transport transition metal ion transport monoatomic ion transport intracellular protein localization monoatomic cation transport	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle ruffle membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle ruffle cell leading edge intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm endosome membrane membrane endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle membrane cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001251	CRAL-TRIO lipid binding domain	Domain
A	IPR000198	Rho GTPase-activating protein domain	Domain
A	IPR036865	CRAL-TRIO lipid binding domain superfamily	Homologous Superfamily
A	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A	IPR049592	Rho GTPase-activating protein 1, RhoGAP domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q07960	astrocytic tumor diabetes mellitus schizophrenia autism spectrum disorder osteoarthritis vascular disease dermatomyositis osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.