Annotations: 1S4Z

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1s4za1	All beta proteins	SH3-like barrel	Chromo domain-like	Chromo domain	Heterochromatin protein 1, HP1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1s4za2	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d1s4zb1	All beta proteins	SH3-like barrel	Chromo domain-like	Chromo domain	Heterochromatin protein 1, HP1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d1s4zb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Chromo domain	8083619	4000375	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Chromo domain-like	8083620	3000161	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Chromo domain-like	8083620	3000161	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Chromo_shadow	e1s4zA1	A: beta barrels	X: SH3	H: Chromo domain-like (From Topology)	T: Chromo domain-like	F: Chromo_shadow	ECOD (1.6)
B	Chromo_shadow	e1s4zB1	A: beta barrels	X: SH3	H: Chromo domain-like (From Topology)	T: Chromo domain-like	F: Chromo_shadow	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
B	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01393	Chromo shadow domain (Chromo_shadow)	Chromo shadow domain	This domain is distantly related to Pfam:PF00385. This domain is always found in association with a chromo domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Chromobox protein homolog 1	histone methyltransferase binding protein binding binding enzyme binding identical protein binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process	membrane-bounded organelle female pronucleus intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus pronucleus intracellular membrane-bounded organelle membraneless organelle intracellular membraneless organelle chromocenter cytoskeleton spindle membrane-bounded organelle female pronucleus intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus pronucleus intracellular membrane-bounded organelle membraneless organelle intracellular membraneless organelle chromocenter cytoskeleton spindle microtubule cytoskeleton membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen chromosome chromosome, telomeric region chromosomal region chromatin pericentric heterochromatin heterochromatin chromosome, centromeric region site of DNA damage male pronucleus
C	Chromatin assembly factor 1 subunit A	protein binding binding chromo shadow domain binding protein domain specific binding identical protein binding	protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization nucleobase-containing compound metabolic process protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization nucleobase-containing compound metabolic process DNA replication metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress DNA repair DNA replication-dependent chromatin assembly	protein-containing complex CAF-1 complex intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000953	Chromo/chromo shadow domain	Domain
A, B	IPR023780	Chromo domain	Domain
A, B	IPR016197	Chromo-like domain superfamily	Homologous Superfamily
A, B	IPR023779	Chromo domain, conserved site	Conserved Site
A, B	IPR008251	Chromo shadow domain	Domain
A, B	IPR051219	Heterochromatin-associated chromo domain-containing protein	Family
A, B	IPR017984	Chromo domain subgroup	Domain
C	IPR029091	Chromatin assembly factor 1 subunit p150, N-terminal	Domain
C	IPR021644	Chromatin assembly factor 1 p150 subunit, acidic region	Domain
C	IPR029105	Chromatin assembly factor 1 subunit p150, C-terminal	Domain
C	IPR022043	Chromatin assembly factor 1 subunit A, dimerization domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.