2OAN | pdb_00002oan

Structure of oxidized beta-actin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2oana2	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	Actin/HSP70	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A	d2oana1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d2oanb2	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	Actin/HSP70	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d2oanb1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d2oanc2	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	Actin/HSP70	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d2oanc1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d2oand2	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	Actin/HSP70	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d2oand1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Actin-like ATPases	8003798	3000092	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Actin-like ATPases	8092404	3000092	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Actin-like ATPases	8092404	3000092	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Actin-like ATPases	8003798	3000092	SCOP2B (2022-06-29)
C	SCOP2 Family	Actin/HSP70	8003797	4000313	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Actin-like ATPases	8092404	3000092	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Actin-like ATPases	8003798	3000092	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Actin-like ATPases	8092404	3000092	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Actin-like ATPases	8003798	3000092	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Actin_1st	e2oanA1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_1st	ECOD (1.6)
A	Actin_2nd	e2oanA2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_2nd	ECOD (1.6)
B	Actin_1st	e2oanB1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_1st	ECOD (1.6)
B	Actin_2nd	e2oanB2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_2nd	ECOD (1.6)
C	Actin_1st	e2oanC1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_1st	ECOD (1.6)
C	Actin_2nd	e2oanC2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_2nd	ECOD (1.6)
D	Actin_1st	e2oanD1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_1st	ECOD (1.6)
D	Actin_2nd	e2oanD2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
A	3.90.640.10	Alpha Beta	Alpha-Beta Complex	Actin	Chain A, domain 4	CATH (4.3.0)
B	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
B	3.90.640.10	Alpha Beta	Alpha-Beta Complex	Actin	Chain A, domain 4	CATH (4.3.0)
C	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
C	3.90.640.10	Alpha Beta	Alpha-Beta Complex	Actin	Chain A, domain 4	CATH (4.3.0)
D	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
D	3.90.640.10	Alpha Beta	Alpha-Beta Complex	Actin	Chain A, domain 4	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Actin, cytoplasmic 1	structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding enzyme regulator activity molecular function regulator activity nitric-oxide synthase regulator activity nitric-oxide synthase binding protein binding enzyme binding identical protein binding cytoskeletal protein binding kinesin binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding Tat protein binding kinase binding protein kinase binding transporter regulator activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	cellular response to nitrogen compound cellular response to stimulus response to cytochalasin B response to stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to cytochalasin B cellular response to chemical stimulus response to chemical cellular process regulation of localization import into cell cellular localization cellular response to nitrogen compound cellular response to stimulus response to cytochalasin B response to stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to cytochalasin B cellular response to chemical stimulus response to chemical cellular process regulation of localization import into cell cellular localization regulation of cellular process regulation of cellular component organization transport synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse cellular component organization localization synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell cellular component organization or biogenesis regulation of endocytosis synaptic vesicle endocytosis regulation of biological process regulation of transport biological regulation regulation of vesicle-mediated transport establishment of localization endocytosis multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development tissue morphogenesis epithelium development morphogenesis of a polarized epithelium morphogenesis of an epithelium tissue development regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress positive regulation of biological process positive regulation of double-strand break repair via homologous recombination regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress recombinational repair positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination positive regulation of cellular process DNA repair positive regulation of DNA recombination double-strand break repair positive regulation of nucleobase-containing compound metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process DNA damage response regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process monoamine transport norepinephrine transport nitrogen compound transport organic hydroxy compound transport organic cation transport catecholamine uptake catecholamine transport regulation of norepinephrine uptake norepinephrine uptake establishment or maintenance of cell polarity protein localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane cell motility adherens junction organization adherens junction assembly cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cell-cell junction assembly cell-cell junction organization transepithelial transport regulation of transepithelial transport apical protein localization protein localization to cell junction protein localization to adherens junction protein localization to cell-cell junction cell cycle regulation of cell cycle	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol apical part of cell cluster of actin-based cell projections brush border synapse cell junction glutamatergic synapse apical junction complex cell-cell junction anchoring junction adherens junction axon neuron projection axon terminus presynapse distal axon calyx of Held neuron projection terminus polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex cell cortex cortical cytoskeleton cell periphery focal adhesion cell-substrate junction postsynapse postsynaptic cytoskeleton postsynaptic actin cytoskeleton protein-containing complex catalytic complex NuA4 histone acetyltransferase complex chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex dense body plasma membrane protein-DNA complex nucleosome cytoplasmic ribonucleoprotein granule ribonucleoprotein granule Schaffer collateral - CA1 synapse tight junction ribonucleoprotein complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR020902	Actin/actin-like conserved site	Conserved Site
A, B, C, D	IPR004001	Actin, conserved site	Conserved Site
A, B, C, D	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A, B, C, D	IPR004000	Actin family	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D	CSD	Parent Component: CYS RESID: AA0262 PSI-MOD : L-cysteine sulfinic acid MOD:00267

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.