2X7C | pdb_00002x7c

Crystal structure of human kinesin Eg5 in complex with (S)-enastron

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2x7cb_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Motor proteins	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2x7ca_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Motor proteins	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	P-loop motor domain	8033968	3002036	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	P-loop motor domain	8033968	3002036	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Kinesin	e2x7cB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Kinesin	ECOD (1.6)
A	Kinesin	e2x7cA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Kinesin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.850.10	Alpha Beta	3-Layer(aba) Sandwich	Kinesin	Kinesin motor domain	CATH (4.3.0)
A	3.40.850.10	Alpha Beta	3-Layer(aba) Sandwich	Kinesin	Kinesin motor domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00225	Kinesin motor domain (Kinesin)	Kinesin motor domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	KINESIN-LIKE PROTEIN KIF11	microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule binding protein binding tubulin binding kinase binding enzyme binding protein kinase binding plus-end-directed microtubule motor activity	cellular process cell cycle mitotic cell cycle cell division microtubule-based movement microtubule-based process spindle elongation microtubule cytoskeleton organization cellular component organization organelle organization nuclear chromosome segregation cellular component organization or biogenesis cytoskeleton organization chromosome segregation cellular process cell cycle mitotic cell cycle cell division microtubule-based movement microtubule-based process spindle elongation microtubule cytoskeleton organization cellular component organization organelle organization nuclear chromosome segregation cellular component organization or biogenesis cytoskeleton organization chromosome segregation spindle organization cell cycle process membraneless organelle assembly cellular component biogenesis cellular component assembly mitotic sister chromatid segregation microtubule cytoskeleton organization involved in mitosis mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly nuclear division mitotic cell cycle process regulation of cellular process centrosome separation mitotic centrosome separation centrosome cycle regulation of cell cycle regulation of biological process microtubule organizing center organization regulation of cell cycle process biological regulation regulation of mitotic centrosome separation	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane cytoplasm cytosol protein-containing complex intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane cytoplasm cytosol protein-containing complex microtubule associated complex kinesin complex membrane-bounded organelle intracellular membrane-bounded organelle mitotic spindle cilium plasma membrane bounded cell projection ciliary basal body cell projection microtubule organizing center polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B	IPR001752	Kinesin motor domain	Domain
A, B	IPR047241	Kinesin-like protein KIF11-like, kinesin motor domain	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR047149	Kinesin-like protein KIF11-like	Family
A, B	IPR025901	Kinesin-associated microtubule-binding domain	Domain
A, B	IPR019821	Kinesin motor domain, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P52732	microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability Chromosomal Instability aneuploidy psoriasis lymphatic system disease malignant glioma medulloblastoma non-alcoholic fatty liver disease adrenal cortex carcinoma osteosarcoma atopic eczema pancreatic intraductal papillary-mucinous neoplasm breast carcinoma endometriosis Sjogren syndrome microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability Chromosomal Instability aneuploidy psoriasis lymphatic system disease malignant glioma medulloblastoma non-alcoholic fatty liver disease adrenal cortex carcinoma osteosarcoma atopic eczema pancreatic intraductal papillary-mucinous neoplasm breast carcinoma endometriosis Sjogren syndrome IgA glomerulonephritis interstitial cystitis lung adenocarcinoma malignant colon neoplasm malignant mesothelioma microcephaly nasopharyngeal carcinoma non-small cell lung carcinoma amyotrophic lateral sclerosis ovarian cancer atypical teratoid rhabdoid tumor pilocytic astrocytoma primitive neuroectodermal tumor glioblastoma ulcerative colitis inflammatory bowel disease invasive ductal breast carcinoma lung cancer malignant ependymoma malignant pancreatic neoplasm oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma breast cancer pituitary cancer ductal breast carcinoma in situ hepatocellular carcinoma intellectual disability large cell medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.