2YGN | pdb_00002ygn

WIF domain of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	WIF	e2ygnA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: WIF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.2170	Mainly Beta	Sandwich	Immunoglobulin-like	Wnt, WIF domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02019	WIF domain (WIF)	WIF domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	WNT INHIBITORY FACTOR 1	protein binding binding signaling receptor binding Wnt-protein binding	cellular response to stimulus regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process signal transduction Wnt signaling pathway regulation of signaling cellular response to stimulus regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process signal transduction Wnt signaling pathway regulation of signaling regulation of biological process cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus biological regulation negative regulation of signal transduction regulation of response to stimulus regulation of cell communication cellular process developmental process fat cell differentiation positive regulation of fat cell differentiation regulation of developmental process cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation regulation of fat cell differentiation positive regulation of cellular process	cellular anatomical structure extracellular region cell surface

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR050969	Developmental Signaling Modulators	Family
A	IPR003306	WIF domain	Domain
A	IPR038677	WIF domain superfamily	Homologous Superfamily
A	IPR013309	Wnt inhibitory factor (WIF)-1	Family
A	IPR013032	EGF-like, conserved site	Conserved Site
A	IPR000742	EGF-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y5W5	colorectal cancer esophageal cancer malignant glioma medulloblastoma neoplasm of esophagus pilocytic astrocytoma psoriasis astrocytic tumor breast carcinoma Colorectal Neoplasms gastric cancer hereditary diffuse gastric adenocarcinoma large cell medulloblastoma malignant colon neoplasm nasopharyngeal carcinoma colorectal cancer esophageal cancer malignant glioma medulloblastoma neoplasm of esophagus pilocytic astrocytoma psoriasis astrocytic tumor breast carcinoma Colorectal Neoplasms gastric cancer hereditary diffuse gastric adenocarcinoma large cell medulloblastoma malignant colon neoplasm nasopharyngeal carcinoma non-small cell lung carcinoma pituitary cancer subependymal giant cell astrocytoma atopic eczema cutaneous lupus erythematosus gastric neoplasm interstitial cystitis lung adenocarcinoma malignant ependymoma malignant tumor of nasopharynx nasopharyngeal neoplasm oligodendroglioma primitive neuroectodermal tumor vascular disease breast cancer colorectal carcinoma glioblastoma invasive ductal breast carcinoma lung carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	MLY	Parent Component: LYS RESID: AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.