3MON | pdb_00003mon

CRYSTAL STRUCTURES OF TWO INTENSELY SWEET PROTEINS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: CATH
Protein Family Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
H	d3mon.8	Alpha and beta proteins (a+b)	Cystatin-like	Cystatin/monellin	Monellin	Monellin, B & A chains together	serendipity berry (Dioscoreophyllum cumminsii ) [TaxId: 3457 ],	SCOPe (2.08)
F	d3mon.7	Alpha and beta proteins (a+b)	Cystatin-like	Cystatin/monellin	Monellin	Monellin, B & A chains together	serendipity berry (Dioscoreophyllum cumminsii ) [TaxId: 3457 ],	SCOPe (2.08)
D	d3mon.6	Alpha and beta proteins (a+b)	Cystatin-like	Cystatin/monellin	Monellin	Monellin, B & A chains together	serendipity berry (Dioscoreophyllum cumminsii ) [TaxId: 3457 ],	SCOPe (2.08)
B	d3mon.5	Alpha and beta proteins (a+b)	Cystatin-like	Cystatin/monellin	Monellin	Monellin, B & A chains together	serendipity berry (Dioscoreophyllum cumminsii ) [TaxId: 3457 ],	SCOPe (2.08)
G	d3mon.8	Alpha and beta proteins (a+b)	Cystatin-like	Cystatin/monellin	Monellin	Monellin, B & A chains together	serendipity berry (Dioscoreophyllum cumminsii ) [TaxId: 3457 ],	SCOPe (2.08)
E	d3mon.7	Alpha and beta proteins (a+b)	Cystatin-like	Cystatin/monellin	Monellin	Monellin, B & A chains together	serendipity berry (Dioscoreophyllum cumminsii ) [TaxId: 3457 ],	SCOPe (2.08)
C	d3mon.6	Alpha and beta proteins (a+b)	Cystatin-like	Cystatin/monellin	Monellin	Monellin, B & A chains together	serendipity berry (Dioscoreophyllum cumminsii ) [TaxId: 3457 ],	SCOPe (2.08)
A	d3mon.5	Alpha and beta proteins (a+b)	Cystatin-like	Cystatin/monellin	Monellin	Monellin, B & A chains together	serendipity berry (Dioscoreophyllum cumminsii ) [TaxId: 3457 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
H	SCOP2B Superfamily	Cystatin/monellin	8043429	3000441	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Cystatin/monellin	8043429	3000441	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cystatin/monellin	8043429	3000441	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cystatin/monellin	8043429	3000441	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
H	6.10.140.2000	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
F	6.10.140.2000	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
D	6.10.140.2000	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
B	6.10.140.2000	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
G	6.20.50.130	Special	Other non-globular	N-terminal domain of TfIIb		CATH (4.3.0)
E	6.20.50.130	Special	Other non-globular	N-terminal domain of TfIIb		CATH (4.3.0)
C	6.20.50.130	Special	Other non-globular	N-terminal domain of TfIIb		CATH (4.3.0)
A	6.20.50.130	Special	Other non-globular	N-terminal domain of TfIIb		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D, F, H	PF09200	Monellin (Monellin)	Monellin	Monellin, a protein produced by the West African plant Dioscoreophyllum cumminsii, is approximately 70,000 times sweeter than sucrose on a molar basis. The protein adopts an alpha-beta structure, with a cystatin-like fold, where each helix packs agai ...	Monellin, a protein produced by the West African plant Dioscoreophyllum cumminsii, is approximately 70,000 times sweeter than sucrose on a molar basis. The protein adopts an alpha-beta structure, with a cystatin-like fold, where each helix packs against a coiled antiparallel beta-sheet [1].	Domain
A, C, E, G	PF09200	Monellin (Monellin)	Monellin	Monellin, a protein produced by the West African plant Dioscoreophyllum cumminsii, is approximately 70,000 times sweeter than sucrose on a molar basis. The protein adopts an alpha-beta structure, with a cystatin-like fold, where each helix packs agai ...	Monellin, a protein produced by the West African plant Dioscoreophyllum cumminsii, is approximately 70,000 times sweeter than sucrose on a molar basis. The protein adopts an alpha-beta structure, with a cystatin-like fold, where each helix packs against a coiled antiparallel beta-sheet [1].	Domain

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D, F, H	IPR053768	Intense Sweet-Taste Modifier	Homologous Superfamily
B, D, F, H	IPR015283	Monellin	Family
B, D, F, H	IPR046350	Cystatin superfamily	Homologous Superfamily
B, D, F, H	IPR002095	Monellin, B chain	Family
A, C, E, G	IPR038580	Monellin, A chain superfamily	Homologous Superfamily
A, C, E, G	IPR015283	Monellin	Family
A, C, E, G	IPR000828	Monellin, A chain	Family
A, C, E, G	IPR046350	Cystatin superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.