3PRY | pdb_00003pry

Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3prya1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Hsp90 middle domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3prya2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3pryb1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Hsp90 middle domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3pryb2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3pryc1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Hsp90 middle domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3pryc2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HSP90_1st	e3pryA1	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: HSP90_1st	ECOD (1.6)
A	HSP90_2nd	e3pryA2	A: a/b three-layered sandwiches	X: HSP90 C-terminal a/b domain (From Topology)	H: HSP90 C-terminal a/b domain (From Topology)	T: HSP90 C-terminal a/b domain	F: HSP90_2nd	ECOD (1.6)
B	HSP90_1st	e3pryB1	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: HSP90_1st	ECOD (1.6)
B	HSP90_2nd	e3pryB2	A: a/b three-layered sandwiches	X: HSP90 C-terminal a/b domain (From Topology)	H: HSP90 C-terminal a/b domain (From Topology)	T: HSP90 C-terminal a/b domain	F: HSP90_2nd	ECOD (1.6)
C	HSP90_1st	e3pryC1	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: HSP90_1st	ECOD (1.6)
C	HSP90_2nd	e3pryC2	A: a/b three-layered sandwiches	X: HSP90 C-terminal a/b domain (From Topology)	H: HSP90 C-terminal a/b domain (From Topology)	T: HSP90 C-terminal a/b domain	F: HSP90_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.230.80	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
A	3.40.50.11260	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.30.230.80	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
B	3.40.50.11260	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.30.230.80	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
C	3.40.50.11260	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00183	Hsp90 protein (HSP90)	Hsp90 protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Heat shock protein HSP 90-beta	enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity RNA binding double-stranded RNA binding binding nucleic acid binding histone deacetylase binding protein binding enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity RNA binding double-stranded RNA binding binding nucleic acid binding histone deacetylase binding protein binding enzyme binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding heat shock protein binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding tau protein binding cell adhesion molecule binding cadherin binding nitric-oxide synthase regulator activity protein kinase regulator activity kinase regulator activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding histone methyltransferase binding molecular function inhibitor activity receptor ligand inhibitor activity protein dimerization activity identical protein binding ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity ATP-dependent protein binding kinase binding unfolded protein binding protein homodimerization activity protein kinase binding TPR domain binding protein domain specific binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity peptide binding DNA polymerase binding disordered domain specific binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process positive regulation of cellular process regulation of protein stability regulation of biological quality protein stabilization ribonucleoprotein complex biogenesis telomerase holoenzyme complex assembly protein-containing complex organization protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein folding primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation developmental process placenta development animal organ development anatomical structure development response to stimulus response to topologically incorrect protein response to stress response to unfolded protein cellular response to stimulus cellular response to heat cellular response to stress response to heat response to abiotic stimulus response to temperature stimulus response to interleukin-4 response to peptide response to chemical response to cytokine cellular response to cytokine stimulus cellular response to interleukin-4 regulation of developmental process cellular developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process negative regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process negative regulation of protein catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis negative regulation of cellular process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of ubiquitin-dependent protein catabolic process negative regulation of catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein metabolic process negative regulation of metabolic process proteasomal protein catabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process regulation of localization regulation of protein localization positive regulation of protein localization to cell surface localization protein localization to cell surface macromolecule localization positive regulation of protein localization regulation of protein localization to cell surface intracellular protein localization supramolecular fiber organization telomere maintenance via telomerase telomere organization chromosome organization DNA metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process RNA-templated DNA biosynthetic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening telomere maintenance nucleic acid biosynthetic process organelle organization DNA biosynthetic process chaperone-mediated protein complex assembly positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway positive regulation of signal transduction cellular response to growth factor stimulus signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction cell communication regulation of transforming growth factor beta receptor signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway positive regulation of signaling negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of protein modification process regulation of post-translational protein modification regulation of protein ubiquitination protein ubiquitination macromolecule modification regulation of protein modification by small protein conjugation or removal protein modification process post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal cell cycle regulation of cell cycle	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol dendrite terminus axon neuron projection plasma membrane bounded cell projection growth cone somatodendritic compartment cell projection distal axon dendritic growth cone dendrite dendritic tree site of polarized growth intracellular organelle membraneless organelle dynein axonemal particle intracellular membraneless organelle protein-containing complex protein folding chaperone complex intracellular protein-containing complex perinuclear region of cytoplasm cell body neuronal cell body mitochondrion intracellular membrane-bounded organelle axonal growth cone pigment granule intracellular vesicle melanosome cytoplasmic vesicle cell surface cell periphery plasma membrane membrane-enclosed lumen ficolin-1-rich granule endomembrane system intracellular organelle lumen organelle lumen ficolin-1-rich granule lumen secretory granule secretory vesicle nucleus nucleoplasm nuclear lumen HSP90-CDC37 chaperone complex aryl hydrocarbon receptor complex receptor complex vesicle lumen cytoplasmic vesicle lumen secretory granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
A, B, C	IPR001404	Heat shock protein Hsp90 family	Family
A, B, C	IPR019805	Heat shock protein Hsp90, conserved site	Conserved Site
A, B, C	IPR020575	Heat shock protein Hsp90, N-terminal	Domain
A, B, C	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B, C	IPR037196	HSP90, C-terminal domain	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: P08238	prostate cancer HIV infectious disease ovarian cancer subependymal giant cell astrocytoma breast cancer gastric carcinoma interstitial cystitis large cell medulloblastoma lymphoplasmacytic lymphoma malignant pancreatic neoplasm oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm Prostatic Neoplasms exocrine pancreatic carcinoma interstitial lung disease prostate cancer HIV infectious disease ovarian cancer subependymal giant cell astrocytoma breast cancer gastric carcinoma interstitial cystitis large cell medulloblastoma lymphoplasmacytic lymphoma malignant pancreatic neoplasm oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm Prostatic Neoplasms exocrine pancreatic carcinoma interstitial lung disease lung adenocarcinoma malignant ependymoma myopathy osteosarcoma plasma cell myeloma rheumatoid arthritis gastric cancer invasive ductal breast carcinoma lung cancer malignant glioma non-small cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.