3VJE | pdb_00003vje

Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus in complex with zaragozic acid A

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SQS_PSY	e3vjeA2	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: SQS_PSY	ECOD (1.6)
B	SQS_PSY	e3vjeB1	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: SQS_PSY	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)
B	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00494	Squalene/phytoene synthase (SQS_PSY)	Squalene/phytoene synthase		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Dehydrosqualene synthase	geranylgeranyl diphosphate synthase activity prenyl diphosphate synthase activity prenyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity squalene synthase [NAD(P)H] activity cation binding ion binding binding metal ion binding small molecule binding	tetraterpenoid metabolic process pigment metabolic process carotenoid biosynthetic process isoprenoid biosynthetic process lipid biosynthetic process pigment biosynthetic process primary metabolic process terpenoid biosynthetic process biosynthetic process tetraterpenoid biosynthetic process metabolic process cellular process terpenoid metabolic process carotenoid metabolic process tetraterpenoid metabolic process pigment metabolic process carotenoid biosynthetic process isoprenoid biosynthetic process lipid biosynthetic process pigment biosynthetic process primary metabolic process terpenoid biosynthetic process biosynthetic process tetraterpenoid biosynthetic process metabolic process cellular process terpenoid metabolic process carotenoid metabolic process isoprenoid metabolic process lipid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR044843	Trans-isoprenyl diphosphate synthases, bacterial-type	Family
A, B	IPR033904	Trans-isoprenyl diphosphate synthases, head-to-head	Domain
A, B	IPR002060	Squalene/phytoene synthase	Family
A, B	IPR019845	Squalene/phytoene synthase, conserved site	Conserved Site
A, B	IPR008949	Isoprenoid synthase domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.