4B94 | pdb_00004b94

Crystal structure of human Mps1 TPR domain

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Mad3_BUB1_I	e4b94A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Mad3_BUB1_I	ECOD (1.6)
B	Mad3_BUB1_I	e4b94B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Mad3_BUB1_I	ECOD (1.6)
C	Mad3_BUB1_I	e4b94C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Mad3_BUB1_I	ECOD (1.6)
D	Mad3_BUB1_I	e4b94D1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Mad3_BUB1_I	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
B	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
C	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
D	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	DUAL SPECIFICITY PROTEIN KINASE TTK	protein serine/threonine/tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity binding kinetochore binding protein tyrosine kinase activity adenyl ribonucleotide binding nucleotide binding protein serine/threonine/tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity binding kinetochore binding protein tyrosine kinase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity identical protein binding protein binding	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling meiotic chromosome segregation sexual reproduction reproductive process organelle fission meiotic cell cycle multicellular organismal reproductive process female gamete generation meiotic cell cycle process gamete generation cellular component organization nuclear division organelle organization female meiotic nuclear division nuclear chromosome segregation meiotic nuclear division cellular component organization or biogenesis cell cycle female meiosis chromosome segregation chromosome segregation cell cycle process localization protein localization to kinetochore protein localization to chromosome protein localization to chromosome, centromeric region protein localization to condensed chromosome protein localization to organelle macromolecule localization intracellular protein localization regulation of cell cycle phase transition negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division negative regulation of mitotic cell cycle negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling mitotic sister chromatid separation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization regulation of cell cycle process sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle regulation of mitotic cell cycle negative regulation of cellular process mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition regulation of cell cycle negative regulation of chromosome separation mitotic nuclear division negative regulation of mitotic cell cycle phase transition chromosome organization negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling negative regulation of chromosome segregation negative regulation of nuclear division negative regulation of organelle organization chromosome separation regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein localization to microtubule cytoskeleton protein localization to cytoskeleton protein localization to meiotic spindle protein localization to meiotic spindle midzone cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation microtubule cytoskeleton organization mitotic spindle organization microtubule-based process cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization mitotic metaphase chromosome alignment metaphase chromosome alignment repair of kinetochore microtubule attachment defect chromosome localization organelle localization repair of mitotic kinetochore microtubule attachment defect regulation of reproductive process meiotic spindle assembly checkpoint signaling regulation of metaphase/anaphase transition of meiotic cell cycle regulation of meiotic cell cycle negative regulation of meiotic chromosome separation negative regulation of meiotic cell cycle phase transition negative regulation of meiotic cell cycle meiotic spindle checkpoint signaling regulation of meiotic chromosome separation negative regulation of metaphase/anaphase transition of meiotic cell cycle metaphase/anaphase transition of meiotic cell cycle meiotic chromosome separation regulation of meiotic cell cycle phase transition meiotic cell cycle checkpoint signaling meiotic cell cycle phase transition negative regulation of reproductive process	cellular anatomical structure membrane intracellular anatomical structure cytoplasm intracellular membraneless organelle chromosome chromosomal region kinetochore intracellular organelle organelle membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex cellular anatomical structure membrane intracellular anatomical structure cytoplasm intracellular membraneless organelle chromosome chromosomal region kinetochore intracellular organelle organelle membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome cytoskeleton spindle microtubule cytoskeleton membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C, D	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, B, C, D	IPR000719	Protein kinase domain	Domain
A, B, C, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR027084	Protein kinase Mps1 family, catalytic domain	Domain
A, B, C, D	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P33981	polycystic ovary syndrome non-small cell lung carcinoma malignant glioma medulloblastoma ovarian cancer pilocytic astrocytoma adrenal cortex carcinoma psoriasis breast cancer endometriosis hepatocellular carcinoma Interstitial fibrosis large cell medulloblastoma malignant colon neoplasm malignant mesothelioma polycystic ovary syndrome non-small cell lung carcinoma malignant glioma medulloblastoma ovarian cancer pilocytic astrocytoma adrenal cortex carcinoma psoriasis breast cancer endometriosis hepatocellular carcinoma Interstitial fibrosis large cell medulloblastoma malignant colon neoplasm malignant mesothelioma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous carcinoma atopic eczema breast carcinoma esophageal adenocarcinoma idiopathic pulmonary fibrosis interstitial lung disease lung adenocarcinoma malignant ependymoma malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor atypical teratoid rhabdoid tumor Sjogren syndrome ductal breast carcinoma in situ glioblastoma IgA glomerulonephritis invasive ductal breast carcinoma lung cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.