4DW7 | pdb_00004dw7

Crystal structure of an active-site mutant of the glycoprotein Erns from the pestivirus BVDV-1 in complex with a CpU dinucleotide

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Ribonuclease_T2	e4dw7B1	A: a+b two layers	X: Ribonuclease Rh-like (From Topology)	H: Ribonuclease Rh-like (From Topology)	T: Ribonuclease Rh-like	F: Ribonuclease_T2	ECOD (1.6)
A	Ribonuclease_T2	e4dw7A1	A: a+b two layers	X: Ribonuclease Rh-like (From Topology)	H: Ribonuclease Rh-like (From Topology)	T: Ribonuclease Rh-like	F: Ribonuclease_T2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.90.730.10	Alpha Beta	Alpha-Beta Complex	Ribonuclease Rh	Chain A	CATH (4.3.0)
A	3.90.730.10	Alpha Beta	Alpha-Beta Complex	Ribonuclease Rh	Chain A	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C [auth H], D [auth I]	5'-R(CPU)-3'	-	-	-
A, B	E(rns) glycoprotein	serine-type exopeptidase activity peptidase activity serine hydrolase activity catalytic activity, acting on a protein serine-type peptidase activity hydrolase activity exopeptidase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA serine-type exopeptidase activity peptidase activity serine hydrolase activity catalytic activity, acting on a protein serine-type peptidase activity hydrolase activity exopeptidase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups serine-type endopeptidase activity RNA binding binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding adenyl ribonucleotide binding adenyl nucleotide binding ATP binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides ATP-dependent activity passive transmembrane transporter activity channel activity transporter activity transmembrane transporter activity phosphorus-oxygen lyase activity endonuclease activity nuclease activity RNA endonuclease activity RNA nuclease activity lyase activity ribonuclease T2 activity nucleic acid conformation isomerase activity isomerase activity helicase activity RNA helicase activity ATP-dependent activity, acting on RNA macromolecular conformation isomerase activity	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process viral genome replication biosynthetic process viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process viral genome replication biosynthetic process viral RNA genome replication metabolic process cellular process macromolecule metabolic process symbiont-mediated perturbation of host defense response symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway symbiont-mediated perturbation of host immune response biological process involved in interaction with host symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated perturbation of host process symbiont-mediated perturbation of host innate immune response symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway import into cell receptor-mediated endocytosis of virus by host cell transport establishment of localization vesicle-mediated transport localization symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transmembrane transport monoatomic ion transmembrane transport monoatomic ion transport viral gene expression viral protein processing virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host symbiont-mediated perturbation of host autophagy symbiont-mediated activation of host autophagy proteolysis protein metabolic process	cellular anatomical structure membrane virion component virion membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum host cell membrane other organism part host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part cellular anatomical structure membrane virion component virion membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum host cell membrane other organism part host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part host cell endomembrane system host intracellular region host cell endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR042542	Peptidase C53, pestivirus Npro, interaction domain	Homologous Superfamily
A, B	IPR030399	Pestivirus NS2, peptidase C74	Domain
A, B	IPR008751	Peptidase C53, pestivirus Npro	Domain
A, B	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
A, B	IPR000280	Pestivirus NS3, peptidase S31	Domain
A, B	IPR042309	Pestivirus envelope glycoprotein E2, domain A	Homologous Superfamily
A, B	IPR011492	Non-structural protein NS3-like, DEAD-box helicase, flavivirus	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR042310	Pestivirus envelope glycoprotein E2, domain B	Homologous Superfamily
A, B	IPR002166	RNA dependent RNA polymerase, hepatitis C virus	Family
A, B	IPR001650	Helicase, C-terminal domain-like	Domain
A, B	IPR042311	Pestivirus envelope glycoprotein E2, domain D	Homologous Superfamily
A, B	IPR021824	Capsid protein C, pestivirus	Domain
A, B	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
A, B	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A, B	IPR032521	Pestivirus envelope glycoprotein E2	Domain
A, B	IPR022120	Pestivirus nonstructural protein 2	Family
A, B	IPR049486	Flavivridae NS3 helicase, C-terminal helical domain	Domain
A, B	IPR007094	RNA-directed RNA polymerase, catalytic domain	Domain
A, B	IPR036430	Ribonuclease T2-like superfamily	Homologous Superfamily
A, B	IPR033130	Ribonuclease T2, His active site 2	Active Site