4ETP | pdb_00004etp

C-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coil

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	P-loop motor domain	8044308	3002036	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	P-loop motor domain	8093000	3002036	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Kinesin	e4etpA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Kinesin	ECOD (1.6)
B	Microtub_bd	e4etpB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Microtub_bd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.850.10	Alpha Beta	3-Layer(aba) Sandwich	Kinesin	Kinesin motor domain	CATH (4.3.0)
B	3.40.850.20	Alpha Beta	3-Layer(aba) Sandwich	Kinesin		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00225	Kinesin motor domain (Kinesin)	Kinesin motor domain		Domain
B	PF16796	Microtubule binding (Microtub_bd)	Microtubule binding	This motor homology domain binds microtubules and lacks an ATP-binding site [1-2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Kinesin-like protein KAR3	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule binding protein binding tubulin binding microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity minus-end-directed microtubule motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	cellular process cell cycle mitotic cell cycle mitotic spindle elongation spindle midzone assembly spindle elongation microtubule cytoskeleton organization membraneless organelle assembly cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cellular component organization or biogenesis chromosome segregation cellular process cell cycle mitotic cell cycle mitotic spindle elongation spindle midzone assembly spindle elongation microtubule cytoskeleton organization membraneless organelle assembly cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation microtubule-based process mitotic spindle midzone assembly cytoskeleton organization cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process ERAD pathway cellular response to stress response to chemical response to stress proteolysis metabolic process protein metabolic process macromolecule metabolic process response to endoplasmic reticulum stress cell division establishment of organelle localization cellular localization sexual reproduction organelle transport along microtubule transport nuclear migration involved in conjugation with cellular fusion reproductive process nucleus localization intracellular transport establishment of localization conjugation with cellular fusion localization organelle localization establishment of localization in cell nuclear migration along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement nuclear migration organelle fusion nucleus organization karyogamy karyogamy involved in conjugation with cellular fusion protein localization to microtubule cytoskeleton establishment of protein localization nitrogen compound transport protein transport along microtubule microtubule-based protein transport protein localization to microtubule organizing center protein localization to spindle pole body intracellular protein localization protein transport along microtubule to mitotic spindle pole body establishment of protein localization to spindle pole body protein transport along microtubule to spindle pole body establishment of protein localization to organelle protein transport macromolecule localization protein localization to cytoskeleton protein localization to organelle protein localization to mitotic spindle pole body intracellular protein transport regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of mitotic spindle organization regulation of cell cycle regulation of biological process regulation of cell cycle process biological regulation regulation of microtubule-based process regulation of spindle organization regulation of organelle organization regulation of microtubule cytoskeleton organization mitotic sister chromatid cohesion sister chromatid cohesion meiotic cell cycle	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton chromosome microtubule organizing center spindle pole body polymeric cytoskeletal fiber intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton chromosome microtubule organizing center spindle pole body polymeric cytoskeletal fiber cytoplasmic microtubule cytoplasm supramolecular fiber microtubule supramolecular polymer supramolecular complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B	Spindle pole body-associated protein VIK1	protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity cytoskeletal protein binding microtubule binding protein binding binding tubulin binding	cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process ERAD pathway cellular response to stress response to chemical response to stress proteolysis cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process ERAD pathway cellular response to stress response to chemical response to stress proteolysis cellular process metabolic process protein metabolic process macromolecule metabolic process response to endoplasmic reticulum stress microtubule-based process cellular component organization organelle organization mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion cellular component organization or biogenesis cell cycle cell cycle process protein polymerization protein-containing complex organization microtubule cytoskeleton organization microtubule polymerization cellular component biogenesis microtubule polymerization or depolymerization cellular component assembly microtubule nucleation protein-containing complex assembly supramolecular fiber organization cytoskeleton organization	protein-containing complex intracellular anatomical structure intracellular membraneless organelle intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle microtubule associated complex kinesin complex microtubule cytoskeleton cytoplasm membrane-bounded organelle nucleus protein-containing complex intracellular anatomical structure intracellular membraneless organelle intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle microtubule associated complex kinesin complex microtubule cytoskeleton cytoplasm membrane-bounded organelle nucleus intracellular membrane-bounded organelle microtubule organizing center spindle pole body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR001752	Kinesin motor domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR027640	Kinesin-like protein	Family
A	IPR019821	Kinesin motor domain, conserved site	Conserved Site
B	IPR031852	Spindle pole body-associated protein Vik1/Cik1, microtubule binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.