4F11 | pdb_00004f11

Crystal structure of the extracellular domain of human GABA(B) receptor GBR2

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ANF_receptor_2nd	e4f11A1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: ANF_receptor_2nd	ECOD (1.6)
A	ANF_receptor_2nd_1	e4f11A2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: ANF_receptor_2nd_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01094	Receptor family ligand binding region (ANF_receptor)	Receptor family ligand binding region	This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Gamma-aminobutyric acid type B receptor subunit 2	protein heterodimerization activity protein binding binding protein dimerization activity G protein-coupled GABA receptor activity GABA receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity	regulation of biological process signaling biological regulation cell-cell signaling neuron-glial cell signaling cellular process cell communication gamma-aminobutyric acid signaling pathway regulation of molecular function negative regulation of lyase activity regulation of adenylate cyclase activity regulation of catalytic activity negative regulation of molecular function negative regulation of catalytic activity regulation of biological process signaling biological regulation cell-cell signaling neuron-glial cell signaling cellular process cell communication gamma-aminobutyric acid signaling pathway regulation of molecular function negative regulation of lyase activity regulation of adenylate cyclase activity regulation of catalytic activity negative regulation of molecular function negative regulation of catalytic activity negative regulation of adenylate cyclase activity trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling chemical synaptic transmission cellular response to stimulus regulation of cellular process response to stimulus adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction synaptic transmission, GABAergic	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane protein-containing complex plasma membrane protein complex membrane protein complex receptor complex cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane protein-containing complex plasma membrane protein complex membrane protein complex receptor complex GABA receptor complex G protein-coupled receptor dimeric complex plasma membrane signaling receptor complex G protein-coupled receptor complex G protein-coupled GABA receptor complex G protein-coupled receptor heterodimeric complex intracellular anatomical structure cytoplasm cell projection neuron projection plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017978	GPCR family 3, C-terminal	Domain
A	IPR017979	GPCR, family 3, conserved site	Conserved Site
A	IPR002457	GPCR family 3, gamma-aminobutyric acid receptor, type B2	Family
A	IPR000337	GPCR, family 3	Family
A	IPR002455	GPCR family 3, GABA-B receptor	Family
A	IPR028082	Periplasmic binding protein-like I	Homologous Superfamily
A	IPR041689	Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain	Domain
A	IPR001828	Receptor, ligand binding region	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O75899	Muscle spasticity of spinal origin nicotine dependence pituitary cancer subependymal giant cell astrocytoma adrenal cortex adenoma atypical teratoid rhabdoid tumor interstitial cystitis major depressive disorder medulloblastoma narcolepsy oligodendroglioma primitive neuroectodermal tumor astrocytic tumor autism developmental and epileptic encephalopathy, 59 Muscle spasticity of spinal origin nicotine dependence pituitary cancer subependymal giant cell astrocytoma adrenal cortex adenoma atypical teratoid rhabdoid tumor interstitial cystitis major depressive disorder medulloblastoma narcolepsy oligodendroglioma primitive neuroectodermal tumor astrocytic tumor autism developmental and epileptic encephalopathy, 59 glioblastoma interstitial lung disease malignant ependymoma neurodevelopmental disorder with poor language and loss of hand skills pilocytic astrocytoma psoriasis atypical Rett syndrome epilepsy intellectual disability large cell medulloblastoma malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.