4MR9 | pdb_00004mr9

Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist SCH50911

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Type 1 solute binding protein-like	8077987	3000125	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ANF_receptor_2nd	e4mr9A2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: ANF_receptor_2nd	ECOD (1.6)
A	ANF_receptor_2nd_1	e4mr9A1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: ANF_receptor_2nd_1	ECOD (1.6)
B	ANF_receptor_2nd	e4mr9B2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: ANF_receptor_2nd	ECOD (1.6)
B	ANF_receptor_2nd_1	e4mr9B1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: ANF_receptor_2nd_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)
B	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01094	Receptor family ligand binding region (ANF_receptor)	Receptor family ligand binding region	This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.	Domain
B	PF01094	Receptor family ligand binding region (ANF_receptor)	Receptor family ligand binding region	This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Gamma-aminobutyric acid type B receptor subunit 1	neurotransmitter receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity G protein-coupled neurotransmitter receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential postsynaptic neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential G protein-coupled GABA receptor activity GABA receptor activity	regulation of biological process signaling biological regulation cell-cell signaling neuron-glial cell signaling cellular process cell communication cellular response to stimulus regulation of cellular process response to stimulus adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction regulation of biological process signaling biological regulation cell-cell signaling neuron-glial cell signaling cellular process cell communication cellular response to stimulus regulation of cellular process response to stimulus adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction trans-synaptic signaling synaptic transmission, GABAergic chemical synaptic transmission synaptic signaling anterograde trans-synaptic signaling gamma-aminobutyric acid signaling pathway	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane protein-containing complex plasma membrane protein complex membrane protein complex receptor complex cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane protein-containing complex plasma membrane protein complex membrane protein complex receptor complex GABA receptor complex G protein-coupled receptor dimeric complex plasma membrane signaling receptor complex G protein-coupled receptor complex G protein-coupled GABA receptor complex extracellular region Schaffer collateral - CA1 synapse G protein-coupled receptor heterodimeric complex presynapse presynaptic membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm GABA-ergic synapse
B	Gamma-aminobutyric acid type B receptor subunit 2	protein heterodimerization activity protein binding binding protein dimerization activity G protein-coupled GABA receptor activity GABA receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity	regulation of biological process signaling biological regulation cell-cell signaling neuron-glial cell signaling cellular process cell communication gamma-aminobutyric acid signaling pathway regulation of molecular function negative regulation of lyase activity regulation of adenylate cyclase activity regulation of catalytic activity negative regulation of molecular function negative regulation of catalytic activity regulation of biological process signaling biological regulation cell-cell signaling neuron-glial cell signaling cellular process cell communication gamma-aminobutyric acid signaling pathway regulation of molecular function negative regulation of lyase activity regulation of adenylate cyclase activity regulation of catalytic activity negative regulation of molecular function negative regulation of catalytic activity negative regulation of adenylate cyclase activity trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling chemical synaptic transmission cellular response to stimulus regulation of cellular process response to stimulus adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction synaptic transmission, GABAergic	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane protein-containing complex plasma membrane protein complex membrane protein complex receptor complex cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane protein-containing complex plasma membrane protein complex membrane protein complex receptor complex GABA receptor complex G protein-coupled receptor dimeric complex plasma membrane signaling receptor complex G protein-coupled receptor complex G protein-coupled GABA receptor complex G protein-coupled receptor heterodimeric complex intracellular anatomical structure cytoplasm cell projection neuron projection plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017978	GPCR family 3, C-terminal	Domain
A	IPR028082	Periplasmic binding protein-like I	Homologous Superfamily
A	IPR002456	GPCR family 3, gamma-aminobutyric acid receptor, type B1	Family
A	IPR000436	Sushi/SCR/CCP domain	Domain
A	IPR002455	GPCR family 3, GABA-B receptor	Family
A	IPR001828	Receptor, ligand binding region	Domain
A	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
B	IPR017978	GPCR family 3, C-terminal	Domain
B	IPR017979	GPCR, family 3, conserved site	Conserved Site
B	IPR002457	GPCR family 3, gamma-aminobutyric acid receptor, type B2	Family
B	IPR000337	GPCR, family 3	Family
B	IPR002455	GPCR family 3, GABA-B receptor	Family
B	IPR028082	Periplasmic binding protein-like I	Homologous Superfamily
B	IPR041689	Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain	Domain
B	IPR001828	Receptor, ligand binding region	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UBS5	alcohol abuse cocaine dependence cocaine abuse lymphoplasmacytic lymphoma medulloblastoma narcolepsy pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma atypical teratoid rhabdoid tumor psoriatic arthritis Autistic Disorder tuberculosis endogenous depression lung cancer malignant ependymoma alcohol abuse cocaine dependence cocaine abuse lymphoplasmacytic lymphoma medulloblastoma narcolepsy pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma atypical teratoid rhabdoid tumor psoriatic arthritis Autistic Disorder tuberculosis endogenous depression lung cancer malignant ependymoma nasopharyngeal disease pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor autism schizophrenia glioblastoma lung carcinoma malignant glioma osteosarcoma Pick disease psoriasis autism spectrum disorder subependymal giant cell astrocytoma cutaneous lupus erythematosus large cell medulloblastoma
B	Pharos: O75899	Muscle spasticity of spinal origin nicotine dependence pituitary cancer subependymal giant cell astrocytoma adrenal cortex adenoma atypical teratoid rhabdoid tumor interstitial cystitis major depressive disorder medulloblastoma narcolepsy oligodendroglioma primitive neuroectodermal tumor astrocytic tumor autism developmental and epileptic encephalopathy, 59 Muscle spasticity of spinal origin nicotine dependence pituitary cancer subependymal giant cell astrocytoma adrenal cortex adenoma atypical teratoid rhabdoid tumor interstitial cystitis major depressive disorder medulloblastoma narcolepsy oligodendroglioma primitive neuroectodermal tumor astrocytic tumor autism developmental and epileptic encephalopathy, 59 glioblastoma interstitial lung disease malignant ependymoma neurodevelopmental disorder with poor language and loss of hand skills pilocytic astrocytoma psoriasis atypical Rett syndrome epilepsy intellectual disability large cell medulloblastoma malignant glioma

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class C	GABA_B receptor ectodomain GBR1-GBR2 heterodimer, apo form

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.