5I0S | pdb_00005i0s

Thiosulfate bound Cysteine Dioxygenase at pH 6.2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5i0sa_	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	Cysteine dioxygenase type I	Cysteine dioxygenase type I	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RmlC-like cupins	8041102	3001825	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CDO_I	e5i0sA1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: CDO_I	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cysteine dioxygenase type 1	cation binding transition metal ion binding ion binding binding nickel cation binding metal ion binding small molecule binding iron ion binding ferrous iron binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity cysteine dioxygenase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity cation binding transition metal ion binding ion binding binding nickel cation binding metal ion binding small molecule binding iron ion binding ferrous iron binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity cysteine dioxygenase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity zinc ion binding	response to acid chemical response to stimulus response to chemical response to amino acid small molecule biosynthetic process organic acid metabolic process organic acid biosynthetic process taurine biosynthetic process taurine metabolic process sulfur compound biosynthetic process alkanesulfonate biosynthetic process biosynthetic process small molecule metabolic process metabolic process response to acid chemical response to stimulus response to chemical response to amino acid small molecule biosynthetic process organic acid metabolic process organic acid biosynthetic process taurine biosynthetic process taurine metabolic process sulfur compound biosynthetic process alkanesulfonate biosynthetic process biosynthetic process small molecule metabolic process metabolic process cellular process sulfur compound metabolic process alkanesulfonate metabolic process response to nitrogen compound response to azide catabolic process serine family amino acid metabolic process oxoacid metabolic process L-cysteine catabolic process sulfur amino acid metabolic process L-cysteine metabolic process amino acid metabolic process organic acid catabolic process alpha-amino acid metabolic process carboxylic acid catabolic process amino acid catabolic process L-amino acid catabolic process carboxylic acid metabolic process primary metabolic process L-amino acid metabolic process cysteine metabolic process proteinogenic amino acid metabolic process serine family amino acid catabolic process sulfur compound catabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process sulfur amino acid catabolic process cysteine catabolic process small molecule catabolic process developmental process regulation of body fluid levels secretion transport mammary gland development gland development animal organ development biological regulation establishment of localization body fluid secretion localization anatomical structure development lactation regulation of biological quality response to hormone response to endogenous stimulus response to peptide hormone response to oxygen-containing compound response to glucagon response to organophosphorus response to purine-containing compound response to cAMP response to corticosteroid response to lipid response to steroid hormone response to glucocorticoid response to alcohol response to ethanol	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR010300	Cysteine dioxygenase type I	Family
A	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily
A	IPR011051	RmlC-like cupin domain superfamily	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	CSS	Parent Component: CYS RESID: AA0269 PSI-MOD : L-cysteine persulfide MOD:00274

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.