6ANJ | pdb_00006anj

Synaptotagmin-7, C2A domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6anja1	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	automated matches	automated matches	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d6anja2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Synaptotagmin-like (S variant)	8072584	4002234	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	C2 domain (calcium/lipid-binding domain, calb)	8072585	3000965	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C2_2	e6anjA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: C2_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00168	C2 domain (C2)	C2 domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Synaptotagmin-7	protein binding binding SNARE binding syntaxin binding calcium-dependent phospholipid binding phospholipid binding lipid binding molecular sensor activity calcium ion sensor activity molecular function regulator activity metal ion sensor activity calmodulin binding modified amino acid binding ion binding protein binding binding SNARE binding syntaxin binding calcium-dependent phospholipid binding phospholipid binding lipid binding molecular sensor activity calcium ion sensor activity molecular function regulator activity metal ion sensor activity calmodulin binding modified amino acid binding ion binding anion binding phosphatidylserine binding small molecule binding clathrin binding cation binding calcium ion binding metal ion binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol bisphosphate binding phosphatidylinositol phosphate binding phosphatidylinositol binding	regulated exocytosis transport secretion export from cell establishment of localization vesicle-mediated transport localization secretion by cell exocytosis cellular process calcium-ion regulated exocytosis import into cell phagocytosis endocytosis regulated exocytosis transport secretion export from cell establishment of localization vesicle-mediated transport localization secretion by cell exocytosis cellular process calcium-ion regulated exocytosis import into cell phagocytosis endocytosis regulation of localization cellular localization regulation of cellular process regulation of cellular component organization synaptic vesicle cycle regulation of synaptic vesicle recycling presynaptic endocytosis vesicle-mediated transport in synapse cellular component organization synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell cellular component organization or biogenesis regulation of endocytosis synaptic vesicle endocytosis regulation of biological process regulation of transport biological regulation regulation of vesicle-mediated transport regulation of phagocytosis establishment of protein localization nitrogen compound transport regulation of hormone secretion regulation of protein localization regulation of peptide secretion signaling hormone secretion protein localization to extracellular region cell communication peptide secretion regulation of secretion by cell amide transport signal release intracellular protein localization regulation of biological quality regulation of peptide hormone secretion regulation of signaling regulation of hormone levels regulation of peptide transport regulation of establishment of protein localization establishment of protein localization to extracellular region cell-cell signaling regulation of protein transport protein secretion regulation of protein secretion regulation of secretion peptide transport protein transport regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport regulation of cell communication insulin secretion synaptic vesicle exocytosis synaptic signaling calcium ion-regulated exocytosis of neurotransmitter trans-synaptic signaling neurotransmitter secretion neurotransmitter transport chemical synaptic transmission signal release from synapse anterograde trans-synaptic signaling regulation of calcium ion-dependent exocytosis positive regulation of biological process positive regulation of secretion by cell positive regulation of exocytosis regulation of regulated secretory pathway positive regulation of secretion positive regulation of regulated secretory pathway positive regulation of cellular process positive regulation of calcium ion-dependent exocytosis positive regulation of transport regulation of exocytosis positive regulation of organelle organization membrane fusion vesicle organization positive regulation of synaptic vesicle fusion to presynaptic active zone membrane regulation of synaptic vesicle membrane organization endomembrane system organization vesicle fusion to plasma membrane positive regulation of synaptic vesicle membrane organization regulation of organelle organization organelle fusion positive regulation of vesicle fusion vesicle fusion positive regulation of cellular component organization organelle membrane fusion calcium-dependent activation of synaptic vesicle fusion regulation of vesicle fusion membrane organization regulation of synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle fusion to presynaptic active zone membrane organelle organization synaptic vesicle membrane organization exocytic process regulation of synaptic plasticity modulation of chemical synaptic transmission short-term synaptic potentiation regulation of trans-synaptic signaling intracellular lipid transport intracellular cholesterol transport vesicle-mediated cholesterol transport lipid localization intracellular transport lipid transport organic hydroxy compound transport intracellular sterol transport cytosolic transport cholesterol transport sterol transport multicellular organismal process tissue remodeling regulation of bone remodeling bone remodeling regulation of multicellular organismal process regulation of tissue remodeling cellular component biogenesis lysosome organization cellular component assembly phagolysosome assembly vacuole organization organelle assembly lytic vacuole organization phagosome-lysosome fusion phagosome maturation monoamine transport regulation of catecholamine secretion dopamine transport catecholamine transport dopamine secretion catecholamine secretion amine transport regulation of amine transport regulation of dopamine secretion calcium ion regulated lysosome exocytosis wound healing response to stimulus plasma membrane repair response to stress plasma membrane organization response to wounding glucagon secretion regulation of glucagon secretion detection of stimulus response to metal ion response to chemical detection of chemical stimulus detection of calcium ion response to calcium ion	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery presynapse synapse cell junction membrane plasma membrane presynaptic membrane plasma membrane region synaptic membrane membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery presynapse synapse cell junction membrane plasma membrane presynaptic membrane plasma membrane region synaptic membrane membrane-bounded organelle dense core granule intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle vesicle somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection glutamatergic synapse phagocytic vesicle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane endocytic vesicle membrane organelle membrane endocytic vesicle vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome peroxisome microbody microbody membrane peroxisomal membrane cell body neuronal cell body transport vesicle membrane synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane exocytic vesicle axon axon terminus distal axon terminal bouton neuron projection terminus early phagosome GABA-ergic synapse neuron to neuron synapse hippocampal mossy fiber to CA3 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR037732	Synaptotagmin 7, C2A domain	Domain
A	IPR000008	C2 domain	Domain
A	IPR001565	Synaptotagmin	Domain
A	IPR037741	Synaptotagmin 7, C2B domain	Domain
A	IPR035892	C2 domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.