6DNO | pdb_00006dno

Crystal structure of Protein Phosphatase 1 (PP1) bound to the muscle glycogen-targeting subunit (Gm)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Metallo-dependent phosphatases	8080445	3001067	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Metallophos_2_1	e6dnoA1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00149	Calcineurin-like phosphoesterase (Metallophos)	Calcineurin-like phosphoesterase	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or ...	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	Domain
A	PF16891	Serine-threonine protein phosphatase N-terminal domain (STPPase_N)	Serine-threonine protein phosphatase N-terminal domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXS140 phosphatase activity cell adhesion molecule binding cadherin binding involved in cell-cell adhesion cadherin binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXS140 phosphatase activity cell adhesion molecule binding cadherin binding involved in cell-cell adhesion cadherin binding protein binding binding cell adhesion mediator activity cell-cell adhesion mediator activity myosin phosphatase activity protein phosphatase binding phosphatase binding protein phosphatase 1 binding enzyme binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity RNA polymerase II CTD heptapeptide repeat modifying activity RNA polymerase II CTD heptapeptide repeat phosphatase activity RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity calmodulin-dependent protein phosphatase activity calcium-dependent protein serine/threonine phosphatase activity RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity ribonucleoprotein complex binding protein-containing complex binding RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity MAP kinase serine/threonine phosphatase activity MAP kinase phosphatase activity	cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus regulation of Wnt signaling pathway signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway biological regulation regulation of signal transduction cell communication regulation of response to stimulus cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus regulation of Wnt signaling pathway signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway biological regulation regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication cellular process signal transduction Wnt signaling pathway telomere maintenance in response to DNA damage telomere organization chromosome organization primary metabolic process DNA metabolic process nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organelle organization cellular response to stress DNA damage response response to stress metabolic process cellular component organization or biogenesis macromolecule metabolic process developmental process multicellular organismal process epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis morphogenesis of a branching structure anatomical structure development epithelial tube morphogenesis morphogenesis of a branching epithelium cell division positive regulation of cell communication positive regulation of signal transduction signal transduction in absence of ligand positive regulation of biological process regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus extrinsic apoptotic signaling pathway in absence of ligand positive regulation of cellular process positive regulation of programmed cell death regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway in absence of ligand apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling protein dephosphorylation dephosphorylation macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression regulation of translation in response to stress translational initiation regulation of biosynthetic process regulation of translational initiation regulation of protein metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of translation regulation of translational initiation in response to stress regulation of macromolecule biosynthetic process regulation of metabolic process rhythmic process circadian regulation of gene expression circadian rhythm response to light stimulus entrainment of circadian clock response to external stimulus regulation of circadian rhythm photoperiodism response to radiation response to abiotic stimulus entrainment of circadian clock by photoperiod regulation of generation of precursor metabolites and energy positive regulation of macromolecule biosynthetic process positive regulation of glycogen metabolic process positive regulation of metabolic process regulation of small molecule metabolic process small molecule metabolic process positive regulation of macromolecule metabolic process carbohydrate biosynthetic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process energy reserve metabolic process positive regulation of carbohydrate metabolic process regulation of glycogen metabolic process monosaccharide metabolic process regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process positive regulation of biosynthetic process regulation of carbohydrate metabolic process regulation of glucose metabolic process carbohydrate metabolic process polysaccharide biosynthetic process glycogen metabolic process generation of precursor metabolites and energy glycogen biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process glucose metabolic process animal organ development respiratory tube development lung development respiratory system development system development catabolic process carbohydrate catabolic process macromolecule catabolic process regulation of glycogen catabolic process glycogen catabolic process regulation of carbohydrate catabolic process glucan catabolic process regulation of catabolic process polysaccharide catabolic process response to metal ion response to chemical response to lead ion	somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body phosphatase complex protein-containing complex protein phosphatase type 1 complex intracellular anatomical structure catalytic complex cytoplasm protein serine/threonine phosphatase complex PTW/PP1 phosphatase complex extracellular exosome somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body phosphatase complex protein-containing complex protein phosphatase type 1 complex intracellular anatomical structure catalytic complex cytoplasm protein serine/threonine phosphatase complex PTW/PP1 phosphatase complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytosol synapse cell junction glutamatergic synapse cell-cell junction adherens junction anchoring junction glycogen granule neuron spine neuron projection dendritic spine plasma membrane bounded cell projection cell projection postsynapse dendrite dendritic tree nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen membraneless organelle nuclear lumen cell periphery plasma membrane membrane presynapse nucleoplasm
B	Protein phosphatase 1 regulatory subunit 3A	protein phosphatase binding phosphatase binding protein phosphatase 1 binding protein binding binding enzyme binding polysaccharide binding carbohydrate binding glycogen binding	regulation of glycogen biosynthetic process regulation of cellular process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process regulation of primary metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process regulation of biosynthetic process carbohydrate metabolic process regulation of biological process regulation of glycogen biosynthetic process regulation of cellular process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process regulation of primary metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process regulation of biosynthetic process carbohydrate metabolic process regulation of biological process polysaccharide biosynthetic process carbohydrate biosynthetic process glycogen metabolic process biological regulation primary metabolic process generation of precursor metabolites and energy regulation of macromolecule metabolic process glycogen biosynthetic process macromolecule biosynthetic process biosynthetic process regulation of polysaccharide biosynthetic process metabolic process cellular process energy reserve metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of carbohydrate biosynthetic process regulation of glycogen metabolic process regulation of metabolic process	cellular anatomical structure membrane phosphatase complex protein-containing complex protein phosphatase type 1 complex intracellular anatomical structure catalytic complex cytoplasm protein serine/threonine phosphatase complex
C	Microcystin-LR	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR050341	Serine/threonine-protein phosphatase PP1 catalytic subunit	Family
A	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
A	IPR004843	Calcineurin-like, phosphoesterase domain	Domain
A	IPR031675	Serine-threonine protein phosphatase, N-terminal	Domain
A	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	Domain
B	IPR005036	CBM21 (carbohydrate binding type-21) domain	Domain
B	IPR050782	Protein phosphatase 1 regulatory subunit 3	Family
B	IPR038175	CBM21 domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P62136	lung adenocarcinoma osteosarcoma severe acute respiratory syndrome lymphoplasmacytic lymphoma ovarian cancer Middle East respiratory syndrome plasma cell myeloma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C	1ZN
C	ACB
C	DAL	RESID: AA0111 , AA0191 PSI-MOD : meso-lanthionine MOD:00120 , D-alanine (Ala) MOD:00198 , D-alanine (Ser) MOD:00858 , D-alanine MOD:00862
C	DAM	RESID: AA0111 , AA0191
C	FGA	RESID: AA0111 , AA0191

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.