6G2A | pdb_00006g2a

Human [protein ADP-ribosylargenine] hydrolase ARH1 in complex with ADP-HPM

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ADP_ribosyl_GH	e6g2aA1	A: alpha bundles	X: ADP-ribosylglycohydrolase (From Topology)	H: ADP-ribosylglycohydrolase (From Topology)	T: ADP-ribosylglycohydrolase	F: ADP_ribosyl_GH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.4080.10	Mainly Alpha	Orthogonal Bundle	ADP-ribosylglycohydrolase fold	ADP-ribosylation/Crystallin J1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03747	ADP-ribosylglycohydrolase (ADP_ribosyl_GH)	ADP-ribosylglycohydrolase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	[Protein ADP-ribosylarginine] hydrolase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding hydrolase activity, acting on glycosyl bonds catalytic activity, acting on a protein hydrolase activity ADP-ribosylarginine hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity potassium ion binding alkali metal ion binding	protein de-ADP-ribosylation macromolecule modification metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR012108	ADP-ribosylarginine hydrolase	Family
A	IPR050792	ADP-ribosylglycohydrolase	Family
A	IPR036705	ADP-ribosylation/Crystallin J1 superfamily	Homologous Superfamily
A	IPR005502	ADP-ribosylation/Crystallin J1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P54922	atypical teratoid rhabdoid tumor interstitial cystitis malignant glioma ovarian cancer systemic lupus erythematosus glioblastoma large cell medulloblastoma non-small cell lung carcinoma pilocytic astrocytoma vitiligo Hashimoto thyroiditis lung carcinoma osteosarcoma primary biliary cholangitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.