6N9M | pdb_00006n9m

Crystal Structure of Adenosine Deaminase from Salmonella typhimurium with Pentostatin (Deoxycoformycin)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6n9ma_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Metallo-dependent hydrolases	automated matches	automated matches	(Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ) [TaxId: 99287 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Adenosine/AMP deaminase	8100311	4003205	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Metallo-dependent hydrolases	8100312	3000428	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	A_deaminase	e6n9mA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: A_deaminase	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00962	Adenosine deaminase (A_deaminase)	Adenosine deaminase		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Adenosine deaminase	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines adenosine deaminase activity hydrolase activity catalytic activity deaminase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2'-deoxyadenosine deaminase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	nucleoside phosphate metabolic process purine ribonucleoside monophosphate biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process nucleobase-containing compound metabolic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process biosynthetic process ribonucleoside monophosphate metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process nucleoside phosphate metabolic process purine ribonucleoside monophosphate biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process nucleobase-containing compound metabolic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process biosynthetic process ribonucleoside monophosphate metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process nucleoside phosphate biosynthetic process metabolic process cellular process small molecule metabolic process ribonucleoside monophosphate biosynthetic process nucleoside monophosphate metabolic process phosphorus metabolic process purine-containing compound salvage purine nucleobase metabolic process nucleobase biosynthetic process purine nucleobase biosynthetic process hypoxanthine biosynthetic process purine-containing compound metabolic process metabolic compound salvage hypoxanthine metabolic process purine-containing compound biosynthetic process nucleobase metabolic process hypoxanthine salvage purine nucleobase salvage glycosyl compound metabolic process catabolic process purine nucleoside catabolic process carbohydrate derivative metabolic process purine ribonucleoside metabolic process carbohydrate derivative catabolic process adenosine catabolic process glycosyl compound catabolic process purine-containing compound catabolic process nucleoside metabolic process nucleobase-containing compound catabolic process adenosine metabolic process nucleobase-containing small molecule catabolic process nucleoside catabolic process small molecule catabolic process ribonucleoside catabolic process purine nucleoside metabolic process purine ribonucleoside catabolic process ribonucleoside metabolic process nucleotide metabolic process nucleoside biosynthetic process carbohydrate derivative biosynthetic process glycosyl compound biosynthetic process inosine metabolic process small molecule biosynthetic process purine ribonucleoside biosynthetic process ribonucleoside biosynthetic process nucleobase-containing small molecule biosynthetic process inosine biosynthetic process purine nucleoside biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001365	Adenosine deaminase domain	Domain
A	IPR032466	Metal-dependent hydrolase	Homologous Superfamily
A	IPR028893	Adenosine deaminase	Family
A	IPR006330	Adenosine/adenine deaminase	Family
A	IPR006650	Adenosine/AMP deaminase active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.