6WJC | pdb_00006wjc

Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth C]	d6wjcc1	Small proteins	Snake toxin-like	Snake toxin-like	Snake venom toxins	automated matches	Eastern green mamba (Dendroaspis angusticeps ) [TaxId: 8618 ],	SCOPe (2.08)
B [auth C]	d6wjcc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Eastern green mamba (Dendroaspis angusticeps ) [TaxId: 8618 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091160	3000473	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091160	3000473	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	Snake toxin-like	8070337	3000545	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_2	e6wjcA2	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_2	ECOD (1.6)
A	Phage_lysozyme_2	e6wjcA1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
B [auth C]	Toxin_TOLIP	e6wjcC1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth C]	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GC ...	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins [1].	Domain
B [auth C]	PF21947	Snake toxin cobra-type (Toxin_cobra-type)	Snake toxin cobra-type	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Muscarinic acetylcholine receptor M1,Endolysin fusion	phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity catalytic activity phospholipase activity lipase activity neurotransmitter receptor activity G protein-coupled amine receptor activity G protein-coupled acetylcholine receptor activity postsynaptic neurotransmitter receptor activity molecular transducer activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity catalytic activity phospholipase activity lipase activity neurotransmitter receptor activity G protein-coupled amine receptor activity G protein-coupled acetylcholine receptor activity postsynaptic neurotransmitter receptor activity molecular transducer activity G protein-coupled receptor activity signaling receptor activity transmembrane signaling receptor activity G protein-coupled neurotransmitter receptor activity acetylcholine receptor activity hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity	regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation positive regulation of biological process establishment of localization localization positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport cellular response to stimulus cellular response to nitrogen compound regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation positive regulation of biological process establishment of localization localization positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport cellular response to stimulus cellular response to nitrogen compound regulation of cellular process response to stimulus signaling cell communication synaptic signaling signal transduction cellular response to acetylcholine response to oxygen-containing compound cell-cell signaling response to nitrogen compound acetylcholine receptor signaling pathway postsynaptic signal transduction cellular response to oxygen-containing compound adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cellular response to chemical stimulus G protein-coupled acetylcholine receptor signaling pathway response to chemical adenylate cyclase-modulating G protein-coupled receptor signaling pathway response to acetylcholine G protein-coupled receptor signaling pathway cellular process adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway multicellular organismal process regulation of body fluid levels system process secretion by tissue digestive system process secretion body fluid secretion digestion saliva secretion regulation of biological quality nervous system process cognition regulation of postsynaptic membrane potential regulation of membrane potential trans-synaptic signaling chemical synaptic transmission anterograde trans-synaptic signaling neuromuscular synaptic transmission regulation of signaling modulation of chemical synaptic transmission regulation of trans-synaptic signaling postsynaptic modulation of chemical synaptic transmission regulation of cell communication developmental process multicellular organism development anatomical structure development nervous system development system development cell population proliferation cellular developmental process neurogenesis regulation of glial cell proliferation gliogenesis cell differentiation regulation of cell population proliferation glial cell proliferation protein localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization positive regulation of establishment of protein localization positive regulation of protein transport cellular macromolecule localization establishment of localization in cell positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation of establishment of protein localization intracellular transport regulation of protein transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport regulation of locomotion locomotion G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus carbohydrate derivative catabolic process catabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process aminoglycan metabolic process peptidoglycan metabolic process metabolic process macromolecule metabolic process symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis exit from host cell viral process cytolysis in another organism viral release from host cell disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing cell wall organization or biogenesis cell wall macromolecule catabolic process cell wall macromolecule metabolic process	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region presynapse presynaptic membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cholinergic synapse glutamatergic synapse Schaffer collateral - CA1 synapse axon axon terminus distal axon neuron projection terminus host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region
B [auth C]	Muscarinic toxin 7	molecular function inhibitor activity molecular transducer activity protein binding binding signaling receptor binding molecular function regulator activity signaling receptor activity signaling receptor inhibitor activity receptor antagonist activity signaling receptor regulator activity toxin activity	-	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000995	Muscarinic acetylcholine receptor family	Family
A	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
A	IPR002228	Muscarinic acetylcholine receptor M1	Family
A	IPR052619	Bacteriophage lysozyme-like	Family
A	IPR001165	T4-type lysozyme	Family
A	IPR034690	Endolysin T4 type	Family
A	IPR002196	Glycoside hydrolase, family 24	Family
A	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
A	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily
B [auth C]	IPR018354	Snake toxin, conserved site	Conserved Site
B [auth C]	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
B [auth C]	IPR054131	Snake toxin cobra-type	Family
B [auth C]	IPR003571	Snake three-finger toxin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P11229	visual epilepsy epilepsy Memory Disorders brain ischemia diabetes mellitus enterocolitis vasomotor rhinitis Parkinson disease atypical teratoid rhabdoid tumor glioblastoma biliary dyskinesia schizophrenia malignant glioma chronic obstructive pulmonary disease uveitis visual epilepsy epilepsy Memory Disorders brain ischemia diabetes mellitus enterocolitis vasomotor rhinitis Parkinson disease atypical teratoid rhabdoid tumor glioblastoma biliary dyskinesia schizophrenia malignant glioma chronic obstructive pulmonary disease uveitis gastric ulcer pilocytic astrocytoma astrocytic tumor iridocyclitis primitive neuroectodermal tumor large cell medulloblastoma medulloblastoma motion sickness cycloplegia oligodendroglioma peptic ulcer disease allergic rhinitis postencephalitic Parkinson disease irritable bowel syndrome psoriasis malignant ependymoma common cold

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth C]	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	G-protein coupled receptors, family A

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth C]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B [auth C]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B [auth C]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	M1 muscarinic acetylcholine receptor in complex with muscarinic toxin 7 (MT7)

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.