7DEJ | pdb_00007dej

Structure of human ORP3 ORD in apo-form

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Oxysterol_BP	e7dejA1	A: beta barrels	X: Oxysterol-binding protein (From Topology)	H: Oxysterol-binding protein (From Topology)	T: Oxysterol-binding protein	F: Oxysterol_BP	ECOD (1.6)
B	Oxysterol_BP	e7dejB1	A: beta barrels	X: Oxysterol-binding protein (From Topology)	H: Oxysterol-binding protein (From Topology)	T: Oxysterol-binding protein	F: Oxysterol_BP	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01237	Oxysterol-binding protein (Oxysterol_BP)	Oxysterol-binding protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Oxysterol-binding protein-related protein 3	sterol binding binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding sterol transfer activity lipid transporter activity lipid transfer activity transporter activity	bile acid biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process steroid metabolic process carboxylic acid metabolic process primary metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process bile acid metabolic process biosynthetic process small molecule metabolic process metabolic process bile acid biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process steroid metabolic process carboxylic acid metabolic process primary metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process bile acid metabolic process biosynthetic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cytosol filopodium tip cell projection actin-based cell projection filopodium plasma membrane bounded cell projection cell periphery plasma membrane perinuclear endoplasmic reticulum perinuclear region of cytoplasm endoplasmic reticulum organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR041680	Pleckstrin homology domain 8	Domain
A, B	IPR001849	Pleckstrin homology domain	Domain
A, B	IPR018494	Oxysterol-binding protein, conserved site	Conserved Site
A, B	IPR037239	Oxysterol-binding protein superfamily	Homologous Superfamily
A, B	IPR000648	Oxysterol-binding protein	Family
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9H4L5	pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome astrocytic tumor cystic fibrosis gastric carcinoma interstitial cystitis lung carcinoma malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma psoriasis subependymal giant cell astrocytoma bipolar disorder ductal breast carcinoma in situ glioblastoma invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome astrocytic tumor cystic fibrosis gastric carcinoma interstitial cystitis lung carcinoma malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma psoriasis subependymal giant cell astrocytoma bipolar disorder ductal breast carcinoma in situ glioblastoma invasive ductal breast carcinoma malignant colon neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm sinusitis ulcerative colitis cutaneous lupus erythematosus endogenous depression IgA glomerulonephritis lung cancer malignant glioma pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.