7G7O | pdb_00007g7o

Crystal Structure of rat Autotaxin in complex with 3-methyl-5-[rac-(3aR,8aS)-6-[2-cyclopropyl-6-(oxan-4-ylmethoxy)pyridine-4-carbonyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carbonyl]-1H-benzimidazol-2-one, i.e. SMILES C1C[C@@H]2[C@H](CCN1C(=O)c1cc(nc(c1)OCC1CCOCC1)C1CC1)CN(C2)C(=O)c1ccc2c(c1)N(C(=O)N2)C with IC50=0.00527031 microM


Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF01033Somatomedin B domain (Somatomedin_B)Somatomedin B domain- Family
PF01663Type I phosphodiesterase / nucleotide pyrophosphatase (Phosphodiest)Type I phosphodiesterase / nucleotide pyrophosphatase- Family
PF01223DNA/RNA non-specific endonuclease (Endonuclease_NS)DNA/RNA non-specific endonucleaseDomain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Isoform 2 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 2