Annotations: 7K3Y

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	GGYAGAS segment 52-58 from the low complexity domain of Keratin-8	scaffold protein binding protein binding binding protein-containing complex binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to biotic stimulus cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling biological regulation cell death extrinsic apoptotic signaling pathway biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to biotic stimulus cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling biological regulation cell death extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway cellular process signal transduction apoptotic process programmed cell death hepatocyte apoptotic process epithelial cell apoptotic process response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to tumor necrosis factor response to chemical tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus response to tumor necrosis factor response to acid chemical response to stress response to hydrostatic pressure response to oxygen-containing compound response to abiotic stimulus response to water cellular developmental process cellular component assembly involved in morphogenesis cell development membraneless organelle assembly muscle cell differentiation cellular component organization cellular component biogenesis muscle structure development striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation sarcomere organization anatomical structure development actin filament-based process cellular component organization or biogenesis developmental process actomyosin structure organization actin cytoskeleton organization organelle assembly anatomical structure morphogenesis myofibril assembly organelle organization anatomical structure formation involved in morphogenesis striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization cell differentiation involved in embryonic placenta development multicellular organismal process placenta development reproductive process chordate embryonic development animal organ development developmental process involved in reproduction embryo development in utero embryonic development multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen nuclear matrix intracellular membraneless organelle Z disc membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen nuclear matrix intracellular membraneless organelle Z disc sarcomere I band membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex cell-cell junction anchoring junction cell junction extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle polymeric cytoskeletal fiber intermediate filament cytoskeleton cytoskeleton intermediate filament cytosol cell periphery sarcolemma plasma membrane membrane costamere apicolateral plasma membrane plasma membrane region nucleoplasm glycoprotein complex protein-containing complex plasma membrane protein complex membrane protein complex dystrophin-associated glycoprotein complex keratin filament

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR032444	Keratin type II head	Domain
A, B	IPR018039	Intermediate filament protein, conserved site	Conserved Site
A, B	IPR003054	Keratin, type II	Family
A, B	IPR039008	Intermediate filament, rod domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P05787	cirrhosis, familial renal cell carcinoma acute liver failure Liver Cirrhosis, Experimental papillary renal cell carcinoma adenocarcinoma chromophobe renal cell carcinoma sarcomatoid renal cell carcinoma granular cell carcinoma liver cancer breast carcinoma cirrhosis of liver tubular adenocarcinoma collecting duct carcinoma cribriform carcinoma cirrhosis, familial renal cell carcinoma acute liver failure Liver Cirrhosis, Experimental papillary renal cell carcinoma adenocarcinoma chromophobe renal cell carcinoma sarcomatoid renal cell carcinoma granular cell carcinoma liver cancer breast carcinoma cirrhosis of liver tubular adenocarcinoma collecting duct carcinoma cribriform carcinoma drug-induced liver injury gastric cancer hereditary diffuse gastric adenocarcinoma cancer prostate carcinoma clear cell renal carcinoma type 2 diabetes mellitus cribriform carcinoma of breast gastric neoplasm liver neoplasm breast cancer precancerous condition psoriasis cleft lip congestive heart failure diabetes mellitus renal carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.